UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 49 / No. 1 / Published : 2013-01

Order : 9, and page :42 - 50

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Original Article :

Correlation between superoxide dismutase serum and sensoryneural hearing disorder in patients with multi drug resistance tuberculosis

Author :

  1. Erna Erlinda*1
  2. Nyilo Purnami*2
  3. Supriyadi*3
  1. Tengku Peukan General Hospital, Blangpidie, Southwest Aceh, Indonesia
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Hearing is one of the most vital functions in life. In order to maintain communication, normal hearing is crucial. Hearing loss can be caused by various drugs or agents that are toxics, one of mentioned is autotoxicity of Kanamycin. Such drug effect can cause sensorineural type of hearing loss. High frequency sensorineural hearing loss is the consequence of post Kanamycin administration in Multi Drug Resistance Tuberculosis (MDRTB) patients. The characteristics of hearing loss are permanent, progressive, bilateral and sometimes accompanied by tinnitus. The objective of this study is to analyze the correlation between superoxide dismutase (SOD) serum level and sensorineural hearing loss in MDRTB patients. The cross-sectional study was conducted in 17 ears of MDRTB patients post Kanamycin administration. Six ears were normal and 11 ears suffered from hearing loss. This study was carried out in MDRTB outpatient department, Dr. Soetomo Hospital of Surabaya, from February to April 2012. The examinations included pure tone audiometry, tympanometry, 10 mm blood from cubital vein in vacuum tube that was sent directly (<1 hour) for SOD serum level check in Laboratory of Dr. Soetomo Hospital, Surabaya. In this study, from total of 17 patients post Kanamycin admisnitration, those who met the criteria consist of 8 men (47,10%) and 9 women (52,90%). Mean pure tone audiometry with intensity ≥ 30 dB were in high frequencies (4000 Hz, 6000 Hz and 8000 Hz). The result of correlation between SOD serum level and hearing loss by Pearson correlation test, based on audiogram were p = 0,076 in frequency 4000 Hz, p = 0,809 in frequency 6000 Hz, and p = 0,974 in frequency 8000 Hz, which showed no significant differences (p > 0,05). There were no correlation between SOD serum level and sensorineural hearing loss in high frequencies. The hearing test results based on intensity level of hearing loss and SOD serum level check by Spearman’s correlation test was p = 0,628, that showed no significant differences (p > 0,05). In conclusion, this study showed that there was no correlation between Pure Tone Average (PTA) at frequencies, 4000 Hz, 6000 Hz, and 8000 Hz, or PTA based on intensity level of hearing loss, with SOD serum level in MDRTB patients. (FMI 2013;49:42-50)

Keyword :

superoxide dismutase, serum, sensorineural, multidrug resistance tuberculosis,


References :

Brummett RE and Fox KE,(1989) Aminoglycoside-induced hearing loss in humans - : Antimicrob Agents Chemother

Duggal P and Sarkar M,(2007) Audiologic monitoring of multi-drug resistant tuberculosis patients on aminoglycoside treatment with long term follow-up - : BMC Ear Nose Throat Disord





Archive Article

Cover Media Content

Volume : 49 / No. : 1 / Pub. : 2013-01
  1. The Effect Of Emotional Quality Management On Cortisol, Tnf-, And Il-2 In Women With Breast Cancer
  2. Reduced Addiction In Drugs Abusers Undergoing Dhikr At Ponpes Inabah Xix Surabaya
  3. Induced Abortion At Midgestation Of Sheep By Stress
  4. Polymerase Chain Reaction Of Mycobacterium Tuberculosis Gyrb Gene Region For Rapid Screening Test Of Pulmonary Tuberculosis
  5. Muscle Glucose Transporter 1 (glut-1) Expression In Diabetic Rat Models
  6. Characterization Of Fertilin Beta Protein Of Human Sperm Membrane. A Candidate For Immunocontraception
  7. Il-2 Level In Diabetic Mice Due To Obesity Is Higher Than That In Healthy Mice
  8. Supportive Pediatric Programs At Kampai Tabu Karambia Community Health Center Towards Mdgs 2015
  9. Correlation Between Superoxide Dismutase Serum And Sensoryneural Hearing Disorder In Patients With Multi Drug Resistance Tuberculosis
  10. Ethanol Extract From Petiveria Alliacea (singolawang) Inhibits The Growth Of Mycobacterium Tuberculosis In Vitro
  11. Acceleration Of Desa Siaga Aktif In Subdistrict Bareng, Jombang, 2012
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  13. Cytological Diagnostic Accuracy In Skin Tumor

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