UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 4 / Published : 2008-10

Order : 7, and page :259 - 263

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Original Article :

Detection of m. tuberculosis and drug sensitivity test from sputum culture of pulmonary tuberculosis patients in dr soetomo general hospital between 2003-2004

Author :

  1. Justinus Frans Palilingan*1
  1. Department of Pulmonology, School of Medicine, Airlangga University, Dr Soetomo General Hospital

Abstract :

In most developing countries, sputum culture and drug-sensitivity tests are not done routinely because lack of shortage of laboratories facilities for culture and drug-sensitivity tests. It is rarely possible, therefore, to prescribe regimens according to laboratory results. Most developing countries suffer from a shortage of financial resources to procure antituberculosis drugs even for new smear-positive pulmonary cases. In addition, the cost of the drugs used in the treatment of drug-resistant tuberculosis is generally, much higher than that of the drugs used in the short-course chemotherapy, and it is rarely possible to cover the cost of secondary drugs unless external financial resources are available. In 2003 there was 133 patients, 81 (60.90%) male and 52 (39.10%) female. The result of the M. tuberculosis culture was 19 positive, 9 (47.37%) male and 10 (52.63%) female with 2 (10.53%) patients positive for MDR-TB. The culture and sensitivity test for the first-line antituberculosis drugs (SIRE) was as follows: sensitive for isoniazid was 9 (47.37%), for rifampin was 16 (84.21%), for streptomycin was 10 (52.63%), and for ethambutol there was 12 (63.16%) patients. Resistance for isoniazid was 10 (52.63%), for rifampin was 3 (15.79%), for streptomycin was 9 (47.37%), and for ethambutol there was 7 (36.84%) patients. 2 patients (10.53%) were MDR-TB and the sensitivity tests result were resistance for all drugs (isoniazid, rifampin, streptomycin and ethambutol). In 2004 there was 56 patients, 90 (57.69%) male and 66 (42.31%) female. The result of the M. tuberculosis culture was 26 positive, 15 (57.69%) male and 11 (42.31%) female and no MDR-TB. The culture and sensitivity test for SIRE was as follows: sensitive for isoniazid was 23 (88.46%), for rifampin was 24 (92.31%), for streptomycin was 16 (61.54%), and for ethambutol there was 12 (46.15%) patients. Resistance for isoniazid was 3 (11.54%), for rifampin was 2 (7.69%), for streptomycin was 10 (38.46%), and for ethambutol there was 14 (53.85%) patients. Regular examination must be done routinely in all patients with pulmonary TB to identify the MDR-TB and treated properly using the second-line drugs.

Keyword :

pulmonary tuberculosis, culture M. tuberculosis, drug sensitivity test, MDR-TB,


References :

Anonymous,(1969) National Tuberculosis and Respiratory Disease Association - : Diagnostic Standards and Classification of Tuberculosis

Cernoch, PL, Enns, RK, Saubolle, MA & Wallace Jr, RJ,(1994) Laboratory Diagnosis of the Mycobacterioses, Cumitech 16A Washington : ASM Press

Mori, T,(2007) MDR-TB its characteristics and control in Asia-Pacific rim symposium in USJCMSP 10th international conference on emerging infectious diseases in the Pacific rim - : Tuberculosis





Archive Article

Cover Media Content

Volume : 44 / No. : 4 / Pub. : 2008-10
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  2. Molecular Analysis Of The Coding Sequence Of Mage-1 Gene From Hepatocelular Carcinoma Patient And Testis
  3. Potential Value Of C-reactive Protein As Inflammation Marker And Il-1β, Tnf- As Pro-inflammatory Cytokine On Disease Activity Of Rheumatoid Arthritis
  4. Cell Surface Her2/neu Oncoprotein Expression In Breast Ductal Carcinoma
  5. Difference In The Productivity Of B-lymphocyte Isolated From Lymph Nodes And That Isolated From Mice Spleen In The Production Of Toxocara Cati Monoclonal Antibody Using Hybridoma Technology
  6. Exploration In The Use Of Medicinal Plant Acanthus Ilicifolius L In The Treatment Of Endothelial Dysfunction
  7. Detection Of M. Tuberculosis And Drug Sensitivity Test From Sputum Culture Of Pulmonary Tuberculosis Patients In Dr Soetomo General Hospital Between 2003-2004
  8. The Pharmacokenetics Of Levofloxacin In Healthy Rabbit Treated With Antacid
  9. Potency Of Lactobacillus Reuteri On Reduced Inflammation In Septic Encephalopathy
  10. Pharmacokinetic Parameters Determination Of A Single 500-mg Oral Dose Of Levofloxacin In Healthy Subjects By Using Blood Data
  11. Encephalopathy And Neuroendocrine Disorder In Septic Shock
  12. Osteoarthritic Pain Treatment With Electroacupuncture
  13. Review Article And Clinical Experience: Astaxanthin – Oxidative Stress – Diabetes Mellitus From Basics To Clinics And From General To Specific

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