UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 2 / Published : 2008-04

Order : 2, and page :71 - 75

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Original Article :

Difference in cyclooxygenase-2 (cox-2) expression between low and high grade papillary carcinoma in human bladder cancer

Author :

  1. Yulizar, DR*1
  2. Hardjowijoto, S*2
  3. Djatisoesanto, W*3
  4. Soemarno, T*4
  1. Department of Urology, Ulin Hospital, Banjarmasin, South Kalimantan
  2. Department of Urology, Airlangga University School of Medicine, Dr Soetomo Teaching Hospital Surabaya
  3. Department of Urology, Airlangga University School of Medicine, Dr Soetomo Teaching Hospital Surabaya
  4. Department of Anatomic Pathology, Airlangga University School of Medicine, Dr Soetomo Teaching Hospital Surabaya

Abstract :

The objective of this study was to improve the estimation of the prognostic behavior by difference of cyclooxygenase-2 (COX-2) expression between low and high grade papillary carcinoma of human transitional cell bladder cancer. We used COX-2 expression as a parameter for prognostic behavior. It was studied by immunohistochemical methods in 36 samples of human transitional cell carcinoma of the bladder from pathology archive. COX-2 immunostaining identifies intracytoplasmic content of COX-2 in human bladder cancer cell, measured by scale of staining which is scored 0 (0-9.9%), 1 (10-49.9%), 2 (50-99.9%) and scale of immunostaining intensity which was scored 0 (negative), 1+ (weak), 2+ (strong). The results of this study revealed that COX-2 immunostaining identified 19 high grade papillary carcinoma (16 samples were 2+(strong), 2 samples were 1+(weak), and 1 sample was 0 (negative) and 17 low grade papillary carcinoma (9 samples were 2+(strong), 3 samples were 1+(weak), and 5 samples were 0 (negative). There was a distribution difference in COX-2 expression between low grade and high grade papillary carcinoma (p = 0.035) analyzed by the Mann-Whitney test, favoring more strong of COX-2 expression in high grade tumor than expected with equal distribution. In conclusions, these findings suggest that the difference in COX-2 expression in may be used as an additional biomarker of its progressiveness.

Keyword :

cyclooxygenase-2, high grade papillary carcinoma , low grade papillary carcinoma, bladder cancer, transitional cell carcinoma,


References :

Bartoletti, R, Cai, T, Nesi, G, Sardi, I, Rizzo, M,(2005) Qualitative and quantitative analysis of angiogenetic factors in transitional cell bladder carcinoma: Relationship with clinical course at 10 years follow-up - : Oncology Reports

Feldman, AR, Kessler, L, Myers, MH, Naughton, MD,(1986) The prevalence of cancer: estimates based on the Connecticut Tumor Registry - : N Engl J Med

Komhoff, M, Guan, Y, Shappell, HW, Davis, L, Jack, G, Shyr, Y, Koch, MO, Shappel, SB, Breyer, MD,(2000) Enhanced expression of cyclooxygenase-2 in high grade human transitional cell bladder carcinoma - : Am J Pathol





Archive Article

Cover Media Content

Volume : 44 / No. : 2 / Pub. : 2008-04
  1. Tgf-β1 As The Trigger Of Pulp Fibroblast Proliferation
  2. Difference In Cyclooxygenase-2 (cox-2) Expression Between Low And High Grade Papillary Carcinoma In Human Bladder Cancer
  3. Detection Of Cytokeratin 19 Mrna In Blood As An Early Marker Of Micrometastatic Tumor Cells Of Nasopharyngeal Carcinoma Patients In Surabaya
  4. Pcr Technique Detection Of Chlamydia Trachomatis Dna Band Using Silver Nitrate Staining
  5. Change Of Cd4 Count, Hsp70 And Anti-hsp70 Levels In Hiv Patients
  6. Hiv/aids Prevalence In Surabaya, Indonesia
  7. Treatment Response And Acute Toxicity Evaluation Of 70 Gray Radiation In Nasopharyngeal Carcinoma Patients In Dr Soetomo Hospital, Surabaya
  8. Pharmacodynamic Effects Of Ligustroside Glycoside (a Cns Active Substance) Isolated From Fraxinus Graffithii Clarke Against Chemically Induced Seizures On Mice
  9. Management Of Acute Glomerulonephritis In A Child With Ischemic Stroke And Hypertensive Crisis
  10. Efficacy Of Orlistat Plus Diet Compared To Diet Alone In Reducing Body Weight And Body Mass Index
  11. Review Article: Pathogenesis Of Repeated Abortion In Polycystic Ovarian Syndrome (pcos)
  12. Review Article: Protein Calorie Malnutrition And Immune Response In Children
  13. Review Article And Clinical Experience: Varenicline (champix®) : A Breakthrough For Smoking Cessation Treatment (an α4ß2 Nicotinic Acethylcholine Receptor Partial Agonist)

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