UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 42 / No. 4 / Published : 2006-10

Order : 2, and page :209 - 212

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Original Article :

Effect of low intensity exercise on glucose intolerance in the depo medroxyprogesterone acetate (dmpa) injected rat

Author :

  1. Bambang Purwanto*1
  2. Lilik Herawati*2
  3. Harjanto JM*3
  1. Department of Physiology Airlangga University School of Medicine, Surabaya
  2. epartment of Physiology Airlangga University School of Medicine, Surabaya
  3. Department of Physiology Airlangga University School of Medicine, Surabaya

Abstract :

Progesterone and derivate of progesterone-only contraceptive, such as injectable depo Medroxyprogesteron acetate (DMPA) increased diabetic risk. Glucose intolerance and hyperinsulinemia were found in women who had been four until twelve month injected 150 mg DMPA. Exercise reduces glucose intolerance in a lot of diabetic patients but the effect of exercise in women who had injected DMPA remains controversial. This study was to measure the effect of low intensity exercise on glucose intolerance injected DMPA rat. Glucose tolerance was tested on 32 female rats which divided into four groups: group 1 was a group of control rats, group 2 had done low intensity exercise, group 3 was injected with 20 mg DMPA each week and the group 4 was DMPA injected rat which had done low intensity exercise for 12 weeks. It was found that plasma glucose rose significantly (p<0.05) after 30 minutes post glucose intraperitoneal (ip) challenge on group 3 and 4 but decreased on group 1 and 2. Plasma glucose delta were as follows: 37.500 ± 6.060; 35.500 ± 0.872; -27.25 ± 0,362; -25.875 ± 1.820. The result showed no differences between group 1 and group 2 also between group 3 and 4 (p>0.05). In conclusion, low intensity exercise did not reduce glucose intolerance on DMPA injected female rat.

Keyword :

DMPA, exercise, intolerance and glucose,


References :

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MA Febbraio,(2001) Effect of the ovarian hormones on GLUT 4 expression and contraction-stimulated glucose uptake no info : AJP Endo

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Archive Article

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  2. Effect Of Low Intensity Exercise On Glucose Intolerance In The Depo Medroxyprogesterone Acetate (dmpa) Injected Rat
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