UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 47 / No. 4 / Published : 2011-10

Order : 7, and page :230 - 233

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Original Article :

Effect of oral-estrogen conjugate on b-lymphocyte proliferation in the peyer’s patches of adult female balb/c mice ileum

Author :

  1. Viskasari Pintoko Kalanjati*1
  2. Joni Susanto*2
  3. Tri Hartini Yuliawati*3
  1. Department of Anatomy and Histology, Faculty of Medicine Airlangga University
  2. Department of Anatomy and Histology, Faculty of Medicine Airlangga University
  3. Department of Anatomy and Histology, Faculty of Medicine Airlangga University

Abstract :

This study was aimed to analyse the effect of oral-estrogen conjugate on B-lymphocytes proliferation that is part of humoral immune system. Modulation of B-lymphocyte number and the germinal centre diameter in peyer’s patches of adult female BALB/C mice ileum (age 2-3 months) were analysed by diastase PAS staining. A total of 40 mice were divided equally into 4 groups (Cerel-Suhl et al. 1999); the 3-weeks treated group and its control group (Prabowo 1997), the 6-weeks treated group and and its control group. Each treated group was given oral-estrogen conjugate emulsion (0,001625 mg/20 gram of bodyweight/days). Data were analysed using unpaired t-test with Levene test and Pearson correlation test, p<0.05 was considered significant. There was a significant difference on the germinal centre diameter of ileum peyer’s patches between the 3-weeks treated group and its control group (p<0.05), whilst both B-lymphocyte number and germinal centre diameter of ileum peyer’s patches in the 6-weeks treated were significantly different compared to those of its control group (p<0.05). In conclusion, oral-estrogen conjugate may modulate component of the immune system. Further studies are needed to seek the duration and clinical effect of these modulations on the overall immune system.

Keyword :

oral contraceptive-pills, cellular , humoral immune response,


References :

Abbas AK, Lichtman AH, Pober JS. ,(1991) Cellular and Molecular Immunology Philadelphia : W.B.Saunders

Cerel-Suhl L, Sylvia Y, Bryan F.,(1999) Update on Oral Contraceptive Pills - : J American Family Physician

Cormack HD.,(1992) Hematopoietic System in HAM’s Histology - : JB Lippincott Company

Grimaldi CM, Cleary J, Dagtas AS, Moussai D, Diamond B,(2002) Estrogen Alters Thresholds for B Cells Apoptosis and Activation - : J Clinical Investigation

Grimaldi CM, Michael DJ, Diamond B,(2001) Cutting Edge: Expansion and Activation of A Population of Autoreactive Marginal Zone B cells in A Model of Estrogen-Induced Lupus - : J Immunol.





Archive Article

Cover Media Content

Volume : 47 / No. : 4 / Pub. : 2011-10
  1. Antibiotic Resistance Control Program (arcp) Improving Antibiotic Use In Pediatric Hematology And Oncology Patients At Dr Soetomo Hospital In 2006 And 2008
  2. Sensitivity And Specificity Of Clinical Features Of Influenza Like Illness And Laboratorical Findings For Diagnosed Influenza A (h1n1) In Children
  3. Risk Factors For Birth Asphyxia
  4. Liver Involvement In Children With Dengue Infection
  5. Mechanical Ventilation Vs Nasal Cpap Duration And The Risk Of Late Onset Sepsis In Premature Babies With Respiratory Distress Syndrome
  6. Nucleic Acid Amplification Of The Rpob Region Of Mycobacterium Tuberculosis In Pulmonary Tuberculosis Diagnosis
  7. Effect Of Oral-estrogen Conjugate On B-lymphocyte Proliferation In The Peyer’s Patches Of Adult Female Balb/c Mice Ileum
  8. The Effect Of Emotional Quality Management On Stress, And Optimism In Women With Breast Cancer
  9. Quality And Efficiency Improvement Of Professional Medical Doctor Education In Public Health Field Using Objective Structured Public Health Examination (osphe) Approach At Faculty Of Medicine Airlangga University
  10. Review Article: Role Of Ve-cadherin In Vascular Permeability Regulation
  11. Depth Of Human Hypophysial Fossa Due To Aging Process: A Morphologic Research

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