UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 48 / No. 1 / Published : 2012-01

Order : 1, and page :1 - 5

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Original Article :

Effect of sodium nitrite (nano2) to erithrocyte and hemoglobin profile in white rat (rattus norvegicus)

Author :

  1. Rini Ambarwati*1
  1. Nursing Department, Health Polytechnique Ministry of Health, Surabaya

Abstract :

Sodium Nitrite (NaNO2) is a food preservative that tend to be misused. Poisoning from Sodium Nitrite that often occurs reduces hemoglobin ability to bind oxygen and the formation reactive oxygen species (ROS) that can changes erythrocyte count and hemoglobin level. This was an experimental laboratories study using Post Test Control Group Design to identify the effect of Sodium Nitrite administration on the profile of erythrocytes, including erythrocytes count, and hemoglobin levels in white rat. Samples comprised 33 male rats (Rattus norvegicus) weight 175 -200 grams, divided into 3 groups, each consisting of 11 rats. Group 1 was the control group, group 2 received Sodium Nitrite of 0.5 mg/200 grams BW rats and group 3 received Sodium Nitrite of 1.5 mg/200 gram BW rats for 30 days. Results of research showed that there was a high difference in means p=0.000 (p<0.05) on erythrocytes count and hemoglobin level. The Sodium Nitrite of 0.5 mg/200gram BW for white rat, which was a safe dose, has already changed erythrocytes count, and Sodium Nitrite of 1.5 mg/200gram BW showed higher changes either in erythrocytes count and hemoglobin level. In conclusion, Sodium Nitrite administration of 0.5 mg/200gram BW/white rat, and 1.5 mg/200gram BW rats can decrease erythrocytes count and hemoglobin level of male white rats.(FMI 2012;48:1-5)

Keyword :

Sodium Nitrite, erythrocyte, hemoglobin,


References :

Afrianti LH,(2010) Pengawet Makanan Alami dan Sintetis Bandung : Penerbit Alfabeta

Bakta IM,(2006) Hematologi Klinik Ringkas Jakarta : Penerbit Buku Kedokteran EGC





Archive Article

Cover Media Content

Volume : 48 / No. : 1 / Pub. : 2012-01
  1. Effect Of Sodium Nitrite (nano2) To Erithrocyte And Hemoglobin Profile In White Rat (rattus Norvegicus)
  2. Synthesis Of Beta Fertilin Protein Polyclonal Antibody Of Human Sperm Membrane As A Candidate For Immunocontraceptive Material
  3. Long-term Glucocorticoids Effects Of Bone Lining Cells Apoptosis
  4. Zinc Sulfate Increases Lymphocyte Cd4 Count In Hiv/aids Patients At Icuid Dr. Soetomo Hospital Surabaya
  5. Support Group Effect On Cd4 Levels In Plwha Who Recieved Art In Upipi Rsud Dr. Soetomo Surabaya
  6. Intensity Of Swimming Exercise As Chronic Stress Induction Towards Expression Of Glucose Transporter 1 (glut1) In Brain Capillary Endothelial Of Rats (rattus Norvegicus)
  7. The Training Of Wiggler Monitoring Of Primary School Teachers And Students In Surabaya To Improve Eradication Of Dengue Hemorraghic Fever
  8. Implementation Of Safety Work For Nurse In Handling Hiv/aids Patients
  9. Case Report: Posterior Interosseous Nerve Compression Syndrome

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