UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 3 / Published : 2014-07

Order : 5, and page :153 - 159

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Original Article :

Effectiveness of fosfomycin on prevention of surgical site infection of closed brain injury patients after craniotomy in emergency unit dr. soetomo hospital

Author :

  1. Nuril Auliya Husna*1
  2. Yulistiani*2
  3. Joni Wahyuhadi*3
  4. Ni Made Mertaniasih*4
  1. Mahasiswa Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Kedokteran
  4. Dosen Fakultas Kedokteran

Abstract :

Prophylactic antibiotics can prevent SSI (Surgical Site Infection) until < 5% in patients undergo craniotomy. Fosfomycin hasspectrum of activity for all susceptible pathogens of SSI in craniotomy (Staphylococcus aureus and Staphylococcus epidermidis) andhas the ability to penetrate into CSF with or without inflammation condition of meninges (fosfomycin AUCCSF/AUCs ratio, withoutinflammation, is 0.09–0.27). An observasional prospective study was conducted to analyze the effectiveness of fosfomycin inpreventing surgical site infection (SSI) post craniotomy procedure at emergency unit of Dr. Soetomo Teaching Hospital Surabayawith incidents of SSI as the parameters (superficial, deep or organ). Inclusion criteria were patients with closed brain injury (mild,moderate, or severe), underwent craniotomy procedure without implant, received fosfomycin as prophylactic antibiotic (2 x 2 g ivwithin 30–60 minutes prior surgical operation), and 30 days after craniotomy procedure, the surgical sites were evaluated. Therewere 30 patients obtained from this study. The incidence of SSI in patients with subdural abcess (categorized as organ SSI) was3,3%. Risk factor found mostly in patient with SSI were smoking history 30 days before surgical procedure, takingimmunosuppressant agents, undergo emergency surgery, operating duration > 3,75 hours and bleeding volume ≥ 1500 mL. Bacteriacausing SSI was Pseudomonas aeruginosa which is sensitive to fosfomycin, piperacillin tazobactam, and meropenem. LOS patientwith SSI 3x longer than without SSI. Fosfomycin effectively prevented SSI in patients with closed brain injury postcraniotomyprocedure at emergency unit of Dr. Soetomo Teaching Hospital Surabaya. (FMI 2014;50:153-159)

Keyword :

closed brain injury, craniotomy, surgical site infection, fosfomycin,


References :

Barker FG,(2007) Efficacy of prophylactic antibiotics against meningitis after craniotomy: a meta-analysis 60, 887-894 : Neurosurgery

Cha KS, Cho OH, Yoo SY,(2010) Risk factors for surgical site infections in patients undergoing craniotomy 40, 298-305 : J Korean Acad Nurs





Archive Article

Cover Media Content

Volume : 50 / No. : 3 / Pub. : 2014-07
  1. Heavy Metal Contamination May Have A Role In Negative Correlation Between Seafood Consumption And Visuo-motor Development Of 1-3 Year-old Children In Subdistrict Bulak, Surabaya
  2. Detection Of Gyra Gene Mutation Region In Fluoroquinolone Resistant Mycobacterium Tuberculosis Isolate From Surabaya Indonesia
  3. Intravenous Vitamin C Administration Decreases Nitric Oxide Serum Level In Severe Burn Injury
  4. The Overview Of Macrophage, Mast Cell, And Lymphocyte Activity In The Efficacy Distinction Of Pain Reduction For Dry And Wet Cupping Therapies
  5. Effectiveness Of Fosfomycin On Prevention Of Surgical Site Infection Of Closed Brain Injury Patients After Craniotomy In Emergency Unit Dr. Soetomo Hospital
  6. Soot Particulate Matter Exposure Increases Interleukin 6 Levels In The Mechanism Of Cardiovascular Disorders
  7. Electric Shock Increases Vcam And Mcp In Mice Endothelial Blood Vessel
  8. Magnesium And Potassium Parenteral Supplementation Does Not Produce Significant Effect On Magnesium And Potassium Serum Level Of Cervical Cancer Patients Receiving Cisplatin Chemotherapy
  9. Effect Of G-csf On Anc Level In All (acute Lymphoblastic Leukemia) Patient With Neutropenia And Febrile Neutropenia During Chemotherapy
  10. Comparative Effectiveness Of Paracetamol And Metamizol As Antipyretics In Patients With Moderate And Severe Brain Injury In Dr. Soetomo Hospital, Surabaya
  11. Analysis Of Complicated Factors Affecting Therapy Effectiveness In Urinary Tract Infections
  12. In Infant With Acute Diarrhea, Nutritional Status Has Correlation With Dehydration Degree, But Not With Mother’s Education And Breastfeeding
  13. The Use Of Antibiotics In Patients With Urinary Tract Infection

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