UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 3 / Published : 2014-07

Order : 7, and page :164 - 171

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Original Article :

Electric shock increases vcam and mcp in mice endothelial blood vessel

Author :

  1. Binti Yunariyah*1
  1. Health Polytechnique, Ministry of Health Surabaya

Abstract :

Stroke is a nervous disorder resulting from several factors, such as infection in body organs, cell regeneration process, geneticproblems, and abnormal blood circulation, causing atherosclerosis, which is started with endothelial dysfunction. From thosefactors, the most predominant is the biological stress. So far, the mechanism of endothelial dysfunction in distress in modern life hasnot been elaborated. This study was performed to experimental animals, comprising 27 samples, which were divided into 3 groups,in the effort to prove the increase of VCAM and MCP in distress mice due to treatment with stressor of electric shock for 15 days.This study used experimental approach by giving severe stress, presenting as electric shock, for 15 days. After the treatment ended,the animals were sacrificed and the heart was taken and subjected to immunohistochemical examination for VCAM and MCP, andhematoxylin eosin for foam cell. Result of ANOVA test revealed that VCAM, subjected to comparative test between posttest andpretest group, had significant difference (p < 0.05). MCP subjected to comparative test between posttest and pretest group revealedsignificant difference (p < 0.05). T-test in foam cell in posttest group also showed significant difference (p < 0.05). This study hasproved that electric shock stressor increased VCAM, MCP in endothelial cells and foam cell in blood vessel in mice heart. Inconclusion, electric shock has effect on endothelial dysfunction in VCAM and MCP in blood vessel endothelium and the formation offoam cell in cardiac arterial blood vessel in Balb/c mice. (FMI 2014;50:164-171)

Keyword :

electric shock, endothelial dysfunction, VCAM, MCP, foam cell,


References :

Wong KS et al,(2003) Long term mortality & recurrent stroke risk among chinese stroke patients with rredominant intracranial aterisclerosis 34, 2361-2366 : Stroke





Archive Article

Cover Media Content

Volume : 50 / No. : 3 / Pub. : 2014-07
  1. Heavy Metal Contamination May Have A Role In Negative Correlation Between Seafood Consumption And Visuo-motor Development Of 1-3 Year-old Children In Subdistrict Bulak, Surabaya
  2. Detection Of Gyra Gene Mutation Region In Fluoroquinolone Resistant Mycobacterium Tuberculosis Isolate From Surabaya Indonesia
  3. Intravenous Vitamin C Administration Decreases Nitric Oxide Serum Level In Severe Burn Injury
  4. The Overview Of Macrophage, Mast Cell, And Lymphocyte Activity In The Efficacy Distinction Of Pain Reduction For Dry And Wet Cupping Therapies
  5. Effectiveness Of Fosfomycin On Prevention Of Surgical Site Infection Of Closed Brain Injury Patients After Craniotomy In Emergency Unit Dr. Soetomo Hospital
  6. Soot Particulate Matter Exposure Increases Interleukin 6 Levels In The Mechanism Of Cardiovascular Disorders
  7. Electric Shock Increases Vcam And Mcp In Mice Endothelial Blood Vessel
  8. Magnesium And Potassium Parenteral Supplementation Does Not Produce Significant Effect On Magnesium And Potassium Serum Level Of Cervical Cancer Patients Receiving Cisplatin Chemotherapy
  9. Effect Of G-csf On Anc Level In All (acute Lymphoblastic Leukemia) Patient With Neutropenia And Febrile Neutropenia During Chemotherapy
  10. Comparative Effectiveness Of Paracetamol And Metamizol As Antipyretics In Patients With Moderate And Severe Brain Injury In Dr. Soetomo Hospital, Surabaya
  11. Analysis Of Complicated Factors Affecting Therapy Effectiveness In Urinary Tract Infections
  12. In Infant With Acute Diarrhea, Nutritional Status Has Correlation With Dehydration Degree, But Not With Mother’s Education And Breastfeeding
  13. The Use Of Antibiotics In Patients With Urinary Tract Infection

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