UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 43 / No. 1 / Published : 2007-01

Order : 5, and page :23 - 27

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Original Article :

Examination of oxldl serum level as the prognosis of acute thrombotic ischemic stroke

Author :

  1. Bertha J Amaheka*1
  2. Moh. Hasan Machfoed*2
  3. Suhartono Taat Putra*3
  1. Department of Neurology Dr M Haulussy Hospital, Ambon
  2. Department of Neurology, Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya
  3. Department of Anatomic Pathology Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya

Abstract :

A serum level of Oxidized Low Density Lipoprotein (oxLDL) has recently been proposed as a biochemic marker of cardiovascular disease in association with atherosclerotic process. Study of oxLDL mechanism and its influence in cerebrovascular disease has not been commonly done and needs more identification. The goal of this study was to examine the serum level of oxLDL as acute ischemic thrombotic stroke prognostic. This study was performed as an analytic observational research, using longitudinal observational study design, from September 2005 to February 2006 in Dr. Soetomo Hospital Surabaya. This study found 40 samples who complied with inclusion and exclusion criteria, which consisted of two groups. Twenty-five samples were stroke group, who were taken twice for oxLDL and National Institute of Health Stroke Scale (NIHSS) examination. The first was performed on arrival to the hospital (= 48 hours after onset) and the second on the tenth day of hospitalization. Fifteen samples were non stroke group whose their vein blood was taken for oxLDL level examination once they came to the hospital. There was positive correlation between oxLDL and NIHSS, proven by Spearman statistical analysis, with correlation coefficient of 0.635 and significance of 0.001 (p< 0.05). There was significant different mean between oxLDL stroke group and non-stroke group, as proved with t test (0.00 < 0.05). However, the different mean test between oxLDL1 and oxLDL2 was not significant (0.47 > 0.05).

Keyword :

OXLDL, atherosclerosis, stroke, NIHSS,


References :

D Brown,(2004) Genetic and Inflammatory Mechanisms in Stroke no info : no info

KL Gillotte,(2000) Oxidized phospholipids, linked to apolipoprotein B of oxidized LDL, are ligands for macrophage scavenger receptors no info : J Lipid Res

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P Holvoet,(1998) Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease New York : Circulation

P Holvoet,(2001) Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease no info : Arterioscler Thromb Vasc Biol

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Archive Article

Cover Media Content

Volume : 43 / No. : 1 / Pub. : 2007-01
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  2. Effect Of Loranthaceae Daendropthoe Species Infusion On Serum Transaminase Level And Hepatic Necrosis In Rats
  3. Glucose 6 Phosphate Dehydrogenase (g6pd) Deficiency In Bad Pregnancy History In St. Vincentius A Paulo Catholic Hospital, Surabaya
  4. Heparin Effect On Vegf And Egfr After Deep Second And Third Degree Burns In Rattus Novergicus Strain Wistar
  5. Examination Of Oxldl Serum Level As The Prognosis Of Acute Thrombotic Ischemic Stroke
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  9. Description Of Urinary Retention In Women A Retrospective Study In Dr Soetomo Hospital Surabaya
  10. Review Article: The Potential Intervention On Apoptosis And Cell Cycle Activity In Rheumatoid Arthritis
  11. Review Article: The Role Of Microglia As Prime Component Of Cns Immune System In Acute And Chronic Neuroinflammation
  12. Review Article And Clinical Experience: A Novel “two-in-one” Drug Fixed Combination Of Ros And Met Its Roles On Ir, Prediabetes, Mets, T2dm And Cvd

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