UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 46 / No. 3 / Published : 2010-07

Order : 13, and page :233 - 236

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Original Article :

Expression of topoisomerase iiα and cyclin d1 proteins in various degrees of breast ductal carcinoma

Author :

  1. Imam Susilo*1
  1. Department of Anatomic Pathology, Airlangga University School of Medicine, Dr Soetomo Teaching Hospital, Surabaya

Abstract :

Breast cancer is the most common malignancy and a major cause of death in women worldwide. Protooncogene cyclin D1 is to control the cell cycle and topoisomerase IIa has an important role in DNA replication as well as a specific target of some chemotherapeutic agents. Amplification of topoisomerase IIa is regarded to a poor prognosis, but it is a good predictor response to cytotoxic chemotherapy. The relationship between the histopathological degree of invasive ductal breast carcinoma and the expression of topoisomerase IIa and cyclin D1 is still unclear. This study aimed to determine the relationship between topoisomerase IIa and cyclin D1 with the histopathological degree of invasive ductal breast carcinoma. In this retrospective and cross-sectional study, researchers obtained the degree of histopathological data from medical records. Immunohistochemical examination of cyclin D1 and topoisomerase IIa was performed on paraffin block specimens from 35 patients with invasive ductal breast carcinoma at the Department of Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital from January to December 2009. Based on the histopathological degree, found 5 cases (14.3%) degree of good, 12 cases (34.3%) moderate and 18 cases (51.4%) degrees bad. The expression of topoisomerase IIa were 62.9% (22 cases) and cyclin D1were were 54.3% (19 cases). It is known that the expression of topoisomerase IIa and cyclin D1 was not related to the histopathological degree of invasive ductal breast carcinoma (p = 0.091). As a conclusion, topoisomerase IIa and cyclin D1 does not play a role in differentiation, proliferation and carcinogenesis of tumor cells in invasive ductal breast carcinoma.

Keyword :

invasive ductal breast carcinoma, topoisomerase II, cyclin D1, histopathological degree,


References :

Kusumowardojo, Panuwun T et al.,(2004) Beberapa Aspek Sitologi & Histologi Kanker Payudara Surabaya : Indonesian Issue on Breast Cancer I

Hellemans P, van Dam AP, Geyskens M, van Oosterom TA et al.,(1995) Immunohistochemical study of topoisomerase IIexpression in primary ductal carcinoma of the breast - : J Clin Pathol

Holley S, Parkers G, Matthias C, Bockmuhl U, Jahnke V, Ledder K, Strange CR, Fryer AA, Hobban PR,(2001) Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck - : American Journal of Pathology





Archive Article

Cover Media Content

Volume : 46 / No. : 3 / Pub. : 2010-07
  1. Socioeconomic And Genetic Factors Influencing The Strength, Weight, Length And Width Measurements Of Children
  2. Glomerular Filtration Rate In Liver Cirrhosis
  3. Antimicrobial Activity Of Mahkota Dewa [phaleria Macrocarpa (scheff). Boerl.] Leaf Extract Against Pseudomonas Aeruginosa By Agar Dilution And Scanning Electron Microscopy
  4. Mapping Pattern Of Core Dna Loci In Forensic Identification Sample Examination Using Polymerase Chain Reaction (pcr) In Loci Csf1po, Tho1 And Tpox
  5. Spatial Analysis Of Dengue Fever Regarding Its Determinant Factors In Bandar Lampung
  6. Inhibition Of The Mitogen Activated Protein Kinase (mapk) In The Inflammatory Pain Like State Using Sb 203580 And Pd 98059 In Mice
  7. Cloning Of Melanoma Antigen-1 (mage-1) Gene From Fine Needle Aspiration Biopsy Of Hepatic Tissue Of Hepatocelluler Carcinoma Patients
  8. Detection Of Urinary Incontinence Affecting Post-menopausal Age Using Ii Q-7 And Udi-6 Questionnaire At Immanuel Teaching Hospital Bandung
  9. Electron Microscopic Scanning Profile Of Balb/c Mice Intestinal Villi After Per Oral Lps (lipopolysaccharide) During Probiotic Induction
  10. Extensive Intensity Exercise Most Effectively Increases Anaerobic Threshold
  11. Pegagan (centella Asiatica) Extract Increases Vaginal Wall Thickness In Menopausal Rats
  12. Review Article: Interval Exercise With 1:1 Work/rest Ratio Decreases The Risk Factors Of Type-2 Diabetes Mellitus And Coronary Heart Disease
  13. Expression Of Topoisomerase Iiα And Cyclin D1 Proteins In Various Degrees Of Breast Ductal Carcinoma

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