UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 46 / No. 4 / Published : 2010-10

Order : 5, and page :257 - 262

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Original Article :

Extract of psidium guajava leaves reduces malondialdehyde in soleus muscle of wistar rats directly after acute physical activity

Author :

  1. Suhartati*1
  2. Muhammad Hanafi*2
  3. Yayuk Susilowati*3
  1. Department of Medical Biochemistry, Airlangga University School of Medicine
  2. Department of Medical Biochemistry, Airlangga University School of Medicine
  3. Department of Medical Biochemistry, Airlangga University School of Medicine

Abstract :

Malondialdehyde (MDA), a product of lipid peroxidation is commonly used as an indicator for oxidative stress. One of the theory stated that the tissue damage caused by free radicals produce MDA. Many researchers report acute treadmill exercise may stimulate the production of reactive oxygen species (ROS). The extract of rose-apple leaf or Psidium guajava contains quecertin which is an antioxidant. This research was carried out to show the effect of rose-apple leaf extract or Psidium guajava as an antioxidant by reducing the MDA concentration in Soleus muscle under acute physical activity. This is a randomized post test only control group design. Rats were divided into four groups. First group is a control group. The second, the third, and the fourth groups were given 2.724 mg/200 g body weight(BW), 5.407 mg/200 g BW, and 10 mg/200g BW respectively, before aerobic swimming exercise. The extract was given daily for six days, but at day six the extract was given before aerobic swimming exercise. Soon after aerobic swimming exercise the animals were sacrificed, MDA determination on Soleus muscle then performed. The data were analyzed by One Way ANAVA and followed by least significance difference test.The result was the second and the third  groups compare the control have a significant difference. Our result showed extract of Psidium guajava leaf given in the dose of 5.407 mg/200 gram body weight has the most significant effect in reducing MDA produces by (acute physical activity.

Keyword :

Aerobic swimming exercise, Oxidative stress, Malondihaldehyde, Psidium guajava leaf,


References :

Ahmed RG,(2005) Is there a balance between oxidative stress and antioxidant defense system during development? - : Med J of Islamic World Academy of Sciences

Amin M,(1996) Penyakit Paru Obstruktif Menahun: Polusi Udara, Merokok dan Alfa 1 Antitripsin - : Airlangga University Press

Halliwel B and Gutteridge JMC,(1999) Free Radical in Biology and Medicine, 3hd ed. New York : Oxford University Press





Archive Article

Cover Media Content

Volume : 46 / No. : 4 / Pub. : 2010-10
  1. Contribution Of Lifestyle And Obesity To The Incidence Of Pre-diabetes
  2. The Importance Of Parenting On Growth And Development In Toddlers
  3. Combination Of Metformin And Hyperbaric Oxygen Therapy Increased Enos Concentration
  4. Description Of Blood Viscosity From Diabetes Mellitus Outpatients In Endocrine Clinic, Aw Sjahranie Hospital, 2009
  5. 2-methoxyethanol Exposure Affects Protein Profile Of Testicular Sperm Membrane In Mice (mus Musculus)
  6. Extract Of Psidium Guajava Leaves Reduces Malondialdehyde In Soleus Muscle Of Wistar Rats Directly After Acute Physical Activity
  7. Occupational Health And Safety Behavior Analysis And Nosocomial Infection Risk In Cleaning Service Workers At Dr. Seotomo Hospital Surabaya
  8. Groundstroke Exercise Combined With Jogging Can Increase The Physical Fitness Of Tennis Players
  9. Hematocrite As A Screening Test Of Iron Deficiency Occurrence In Tetralogy Of Fallot
  10. Comparison Of Maternal Zinc Level In Term Pregnancy Associated With Premature Rupture Of Membranes In Normal Pregnancy
  11. Predominance Of Right Hemisphere In Post-ischemic Stroke Immunity Modulation
  12. Screening In Proteinuria-hematuria Among 5 - 26 Years Old Students In Closed Community School In Surabaya, Indonesia
  13. Non-specific Pattern Of Ultrasonogram (usg) In Lymphoma Of The Breast
  14. Hormonal Status (estrogen Receptors - Progesterone) And Her-2 Neu In Various Cyclin D1 Expressions In Breast Cancer

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