UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 42 / No. 1 / Published : 2006-01

Order : 8, and page :47 - 53

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Original Article :

Fev1-reversibility in house-dust immunotherapy compared with inhaled corticosteroid in the treatment of childhood asthma

Author :

  1. Arijanto Harsono*1
  2. Lisa A Subrata*2
  3. Anang Endaryanto*3
  1. Division of Allergy and Immunology, Department of Child Health, Airlangga University School of Medicine Dr. Soetomo Teaching Hospital, Surabaya
  2. Division of Allergy and Immunology, Department of Child Health, Airlangga University School of Medicine Dr. Soetomo Teaching Hospital, Surabaya
  3. Division of Allergy and Immunology, Department of Child Health, Airlangga University School of Medicine Dr. Soetomo Teaching Hospital, Surabaya

Abstract :

Asthma is a chronic inflammatory disease of the airway. Corticosteroid is the drug of choice to control the inflammation, and prevent the development of airway hyper responsiveness and later airway remodeling. House dust immunotherapy has been shown to be effective in patients with asthma, and also in those who do not respond well to standard drug therapy. Whether immunotherapy is as effective as inhaled corticosteroid need to be studied. The objective of this study is to investigate the ability of house dust immunotherapy to improve clinical index in children with asthma, and to compare its efficacy with inhaled corticosteroid. We evaluated the beneficial effect of house dust immunotherapy in 24 asthmatic children based on the value of FEV1 reversibility before and after treatment, and also compared its efficacy to the inhaled corticosteroid. All the patients were sensitive to house dust allergen. Twenty-four children (group I) treated with house-dust immunotherapy subcutaneously, once a week for 14 weeks, and group II treated with inhaled budesonide 100-200 μg once daily. The result of Wilcoxon Signed Rank Test showed there was a significant improvement between FEV1 reversibility test before and after house-dust immunotherapy (p=0.0001). Analysis with t-test also revealed that the efficacy of house dust immunotherapy did not differ from inhaled budesonide (p=0.872). In conclusion house dust immunotherapy has been shown to be as effective as inhaled corticosteroid in improving clinical outcome in the term of FEV1-reversibility in the treatment of childhood asthma.

Keyword :

Childhood asthma, house dust immunotherapy, inhaled corticosteroid, FEV1 reversibility,


References :

IT Abba,(2003) Allergy desensitization New York : Marcel Dekker

CA Akdis,(1998) Role of interleukin 10 in specific immunotherapy no info : J Clin Invest

T Blesken,(1998) Role of interleukin 10 in specific immunotherapy no info : J Clin Invest

M Akdis,(1998) Role of interleukin 10 in specific immunotherapy no info : J Clin Invest

P Bradding,(1995) Mast cells and basophiles: their role in initiating and maintaining inflammatory responses London : Academic Press

AF Walls,(1995) Mast cells and basophiles: their role in initiating and maintaining inflammatory responses London : Academic Press

MK Church,(1995) Mast cells and basophiles: their role in initiating and maintaining inflammatory responses London : Academic Press

G Brusselle,(2004) Allergen induced airway inflammation and bronchial responsiveness in wild type and interleukin-4-de.cient mice no info : Am J Respir Cell Mol Biol

J Kips,(2004) Allergen induced airway inflammation and b



Archive Article

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Volume : 42 / No. : 1 / Pub. : 2006-01
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  7. Multiresistance Pattern Of Extended Spectrum β-lactamase (esbl) – Escherichia Coli And Klebsiella Pnemoniae Strains
  8. Fev1-reversibility In House-dust Immunotherapy Compared With Inhaled Corticosteroid In The Treatment Of Childhood Asthma
  9. Trachoma In Pondok Pesantren Salafiyah Syafiiyah, Sukorejo, Situbondo, East Java. A Case Study
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