UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 41 / No. 2 / Published : 2005-04

Order : 3, and page :85 - 89

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Original Article :

Gastroprotective effect of curcumine on ethanol-induced gastric mucosal lesions in rats

Author :

  1. Sri Agus Sudjarwo*1
  1. Department of Pharmacology Airlangga University School of Medicine

Abstract :

This study was conducted to investigate the protective effect of curcumine (50 mg/kg/day; 100 mg/kg/day and 200 mg/kg/day orally for 15 days) in ethanol-induced gastric mucosal lesions in male Wistar rats. Ulceration was induced in rats by administering 50 % ethanol orally. On day 16, the stomach was examined for ulcer by the severity of hemorrhagic erosions in acid secreting glandular mucosa. Total acid and peptic activity were determined in gastric juice using hemoglobin as substrate. Reduce glutathione (GSH) and glutathione peroxidase (GPX) were also estimated from gastric mucosa. Pretreatment with curcumine 100 mg/kg/day and 200 mg/kg/day for 15 days significantly reduced the incidence and severity of gastric erosions induced by ethanol. Curcumine treatment also favorably altered changes in volume and peptic activity of gastric juice in ethanol-treated animals. Furthermore, the levels of GSH and GPX were significantly decreased after treatment with ethanol, and this decrease was prevented by curcumine. The study provides evidence for possible involvement of glutathione in the curcumine-mediated gastroprotection against ethanol-induced ulceration.

Keyword :

curcumine, ethanol, gastric mucosal lesions,


References :

Grossman MI,(1978) Control of gastric secretion: In: Gastrointestinal Disease, Pathophysiology, Diagnosis and Management. Sleisenzer MH, Fordtran JS, editors. 2 ed. Philadelphia : WB Saunders Co

Gunzler WA, Flohe L,(1985) Glutathione peroxidase. In: GreenwalRA, editor. CRC hand book of methods for oxygen radical research. Boca Raton : CRC Press





Archive Article

Cover Media Content

Volume : 41 / No. : 2 / Pub. : 2005-04
  1. Editorial Vol 41 No 2 2005
  2. Opinion: Bioethics. Its Role In Research
  3. Gastroprotective Effect Of Curcumine On Ethanol-induced Gastric Mucosal Lesions In Rats
  4. Spermatozoa Motility And Morphological Recovery Process In Mice (mus Musculus) After The Induction Of 2-methoxyethanol
  5. Nutritional And Immune Effects Of Early Enteral Feeding Supplemented By Arginine, Glutamine And Omega 3 Fatty Acid In Critically Ill Patients
  6. The Comparison Of The Effectiveness Between 2.5% Povidone-iodine Eye Drop And 1% Tetracycline Eye Ointment On Bacterial Ophthalmia Neonatorum Prophylaxis
  7. The Effectiveness Test Of Eyedrop Lodoxamide Tromethamine 0.1 % And Sodium Cromoglycate 2% In Vernal Keratoconjunctivity In Dr. Soetomo Hospital, Surabaya
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  9. Brain Natriuretic Peptide As An Indicator Of Left Ventricle Dysfunction And A Predictor Of Cardiovascular Events In Acute Coronary Syndromes
  10. Management Of Perioperative Pulmonary Edema In Patient With Pre-eclampsia/eclampsia Undergoing C-section
  11. Water Source As The Risk Factor Of H. Pylori Infection In Chidren Aged 0 - 5 Years In Suburban Area Of Surakarta
  12. Clinical–epidemiological Data On Hiv/aids Patients Admitted To A Top Referral Hospital During 1997-2005. A Database For Action In The Future, Referring To Another Developing Countries
  13. Review Article And Clinical Experience: New Insights Into Oral Agents In The Treatment Of T2dm (the Roles Of Fixed-dose Oral Agents Combination)
  14. Literature Review: Choosing A Prosthetic Heart Valve

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