Folia Medica Indonesiana
ISSN 0303-7932
Vol. 49 / No. 1 / Published : 2013-01
Order : 7, and page :33 - 35
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Original Article :
Il-2 level in diabetic mice due to obesity is higher than that in healthy mice
Author :
- Dewi Arni K*1
- Dewi Ratna S*2
- Department of Anatomy and Histology Faculty of Medicine, Airlangga University Surabaya
- Department of Anatomy and Histology Faculty of Medicine, Airlangga University Surabaya
Abstract :
The prevalence obesity in the world grows up every years. One of obesity complication is the decrease of immune response. Mechanism of this complication has not been clear yet. This research studied mechanism the decrease of immune response in obesity which become diabetes by measuring Interleukin (IL)-2 cytokine level in mice. Thirty six mice BALB/c strain, male, 12 weeks years old, weight 25 – 30 g and healthy were classified into 2 groups : control and treatment groups. The control group had standard diet, while the treatment group had high fat diet with 22.8 % fat to induce diabetes for ten weeks. After that, both groups were induced with histamine intraperitoneally then the blood were taken for measuring level of IL-2 with ELISA reader. The IL-2 level of the treatment was found to be significantly higher than the control (p<0,0001). In conclusion, there is no decrease of IL-2 in diabetic causes obesity. (FMI 2013;49:33-35)
Keyword :
References :
Abbas AK and Lichtman AHH,(2004) Basic Immunology: Functions and Disorders of the Immune System, 2nd ed Philadelphia : Elsevier Saunders
Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B,(2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance - : Eur Cytokine Netw
Archive Article
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 Volume : 49 / No. : 1 / Pub. : 2013-01 |
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