UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 3 / Published : 2008-07

Order : 9, and page :184 - 187

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Original Article :

Lactate dehydrogenase level and the response of non hodgkin lymphoma patients to chemotherapy cyclophosphamide doxorubicin, vincristine, prednisone (chop) an observational, prospective, cross-sectional study at the department of internal medicine, dr soetomo hospital, surabaya

Author :

  1. Ugroseno *1
  2. Muhamad Ali *2
  3. Boediwarsono*3
  1. Department of Internal Medicine Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya
  2. Department of Internal Medicine Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya
  3. Department of Internal Medicine Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya

Abstract :

Non-Hodgkin Lymphoma (NHL) is a primary malignancy of solid lymphoid tissue. The disease is distributed around the world with increasing incidence. The sign and symptoms of NHL are: enlargement of the lymph nodes, fever, loss of body weight, night sweating, and pruritus. Chemotherapy is the main treatment modality for aggressive (intermediate and high grade) lymphomas, but only a few patients achieve remission. Several factors such as age, clinical stadium, number of extra nodal region(s), and Lactate Dehydrogenase (LDH) level played a role in determining response to chemotherapy. The association of LDH level as a prognostic factor of chemotherapy in NHL patients has not yet been studied in Dr. Soetomo Hospital. The objective of this study was to determine the association between LDH levels to the response of NHL patients to chemotherapy CHOP. This was an observational analytic, prospective cross sectional study was done in 31 patients with NHL in Dr. Soetomo Hospital Surabaya. Patients were recruited from both inpatient and outpatient clinic. NHL patients who received 3 cycles of chemotherapy with Cyclophosphamide, Doxorubicine, Vincristine, and Prednisone (CHOP) were included. Demographic data (age, sex), the stadium, number of extra nodal region(s) involved, LDH level, and response to chemotherapy were recorded. Results revealed that of the 31 patients who included in this study, the age ranged from 33-60 year. Male to female ratio was 1,6:1. Most of them (74.19%) were on stage II, while 25,81% were on stage III. LDH levels were normal in 51,61% of the patients, and considered high in the rests (48.39%). Results of the chemotherapy were good response in 74.2% and no response in 25.8%. Compared to the patients who showed good response to chemotherapy, patients without chemotherapy response had significantly higher levels of LDH (Odd ratio: 13.125; 95%CI: 1.364 – 126.305; p=0.015). In conclusion, in NHL patients, there is association between the level of LDH and the response of the treatment. In normal level of LDH patients showed the result of the treatment is better than the high level of LDH.

Keyword :

lactate dehydrogenase, non-Hodgkin lymphoma, chemotherapy, cyclophosphamide, doxorubicin,


References :

Armitage, J,(1993) Treatment of Non-Hodgkin Lymphoma - : The New Eng J Med

Bremnes, RM, Bremnes, Y, Domnem, T,(1998) High grade Non-Hodgkin Lymphoma in Northern Norway. Treatment, outcome, and prognostic factors - : Cancer





Archive Article

Cover Media Content

Volume : 44 / No. : 3 / Pub. : 2008-07
  1. Effect Of Hsp70 Expression On T-cd4+ Lymphocyte Apoptosis In Hiv/aids Infection
  2. Ifn-γ In Peripheral Blood Mononuclear Cells And Bronchoalveolar Lavage Patients With Pulmonary Tuberculosis Before And After Treatment With Oral Anti-tuberculosis Drugs
  3. Effect Of Cigarette Smoke Exposure On The Expression Of Mutant P53 In Transitional Cells Of The Bladder An Experimental Study On Rattus Norvegicus
  4. Effect Of High Salt (sodium Chloride) Intake On Fracture Risk In Male White Rats (rattus Norvegicus) An Experimental Laboratory Study
  5. Vibrio Cholerae And Its Typing Profile
  6. Change Of Il-1 Concentration And Intracellular Calcium (ca2+ Ic) As An Indicator Of Increased Bitter Taste In Thypoid Fever
  7. Enriching Communication Behavior Change Framework With Religious Element To Increase Compliance In Taking Anti-tuberculous Drugs
  8. Cognitive Function Disorder As A Reflection Of Immunity Status In People Living With Hiv/aids
  9. Lactate Dehydrogenase Level And The Response Of Non Hodgkin Lymphoma Patients To Chemotherapy Cyclophosphamide Doxorubicin, Vincristine, Prednisone (chop) An Observational, Prospective, Cross-sectional Study At The Department Of Internal Medicine, Dr Soetomo Hospital, Surabaya
  10. Fibular Autostrutgraft As The Optional Treatment Of The Femoral Neck Fractures In Surabaya
  11. The Existence Of A Peak In Adolescent’s Height Increments
  12. Review Article And Clinical Experience: Graves’ Disease And Thyroid Storm: Classical And Non-classical (from Formula G/o: P-39.5 – 120 & Bw-score To Formulas Ts-41668 & Cs-7.1.5)
  13. Review Article: The Effects Of Chlamydia Trachomatis Infection On Women’s Reproduction System

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