Folia Medica Indonesiana
ISSN 0303-7932
Vol. 48 / No. 1 / Published : 2012-01
Order : 3, and page :12 - 16
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Original Article :
Long-term glucocorticoids effects of bone lining cells apoptosis
Author :
- Gadis Meinar Sari*1
- Dosen Fakultas Kedokteran
Abstract :
The aim of this study was to count the amount of apoptotic bone lining cells after long term glucocorticoid distribution. This study used Rattus Norvegicus females aged 3 months that were divided into 3 groups, each group consisted of 7 rats. The groups are: (1) control group; (2) treatment group 1 were given glucocorticoid 0,01 mg/day; (3) treatment group 2 were given glucocorticoid 0,2mg/day. The treatment carried out for 4 weeks and at the end of treatment, mice were sacrified and continued with preparation, and the number of bone lining cells that undergoing apoptosis was calculated through examination of the femur bone tissue metaphysis section using immunohistochemical technique. All data were analyzed with statistical analysis Anova. The result showed that the number of apoptotic bone lining cells is increased in group with glucocorticoid administration 0.01 mg/day and 0.2 mg/day compared to control group with p= 0.000 (p <0.05). The number of apoptotic bone lining cells on the group of glucocorticoid dose 0.2 mg/day higher than the group of glucocorticoid dose 0.01 mg/day with p= 0.000 (p <0.05). In conclusions long term glucocorticoid distribution increase apoptosis of bone lining cells.(FMI 2012;48:12-16)
Keyword :
Bone lining cells, apoptosis, glucocorticoid,
References :
Abu EO, Horner A, Kusec V, Triffitt JT, Compston JE,(2000) The localization of the functional glucocorticoid receptor alpha in human bone - : J Clin Endocrinol Metab
Adler RA and Hochberg MC,(2003) Suggested guidelines for evaluation and treatment of glucocorticoid-induced osteoporosis for the Department of Veterans Affairs - : Arch Intern Med
Archive Article
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 Volume : 48 / No. : 1 / Pub. : 2012-01 |
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