UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 1 / Published : 2008-01

Order : 5, and page :21 - 23

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Original Article :

Molecular expression of estrogen receptor alpha (erα) and interleukin 6 (il-6) on acceleration of healing process of long bone shaft fracture by immediate repetitive axial compression tension stabilization (ireact)

Author :

  1. Achmad Sjarwani*1
  1. Department of Orthopaedics, Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Jl Prof Dr Moestopo 6-8, Surabaya

Abstract :

Long bone fracture healing depends on multifactorial aspects, which are basically divided into general and local. Healing of long bone fracture naturally needs 3 to 6 and sometimes up to 9 months period, which is considered a high morbidity not only for the patient, but also for his/her family and the society in accordance of psychosocioeconomic field. The aim of this study was to know the mechanism process of immediate and repetitive loading (IREACTS) to accelerate healing process of long bone fracture. Estrogen receptor alpha (ER α) and interleukin 6 (IL6) were determined by immunohistochemistry technique and ELISA. Research samples were bone tissue and serum prepared from immediate and repetitive loading (IREACTS) compared to fracture without loading. The result showed that healing process occurred more rapidly on immediate and repetitive loading (IREACTS) compared to fracture without loading based on the expression of ER α and IL6 of bone tissues and serum. In conclusion, IREACTS induces the mechanism to achieve bone healing by the process of secondary bone healing and can be used as a method for lowering morbidity in patients with long bone fracture.

Keyword :

IREACT, Estrogen receptor a, IL-6,


References :

Oppenheim, JJ, Rosio, JL, Geary, AJH,(1993) Clinical application of cytokine, in Cytokine and Bone Remodelling New York : Oxford Publisher

Duncan, RL & Turner, CH,(1995) Mechanotransduction and the functional response of bone to mechanical strain - : Calcif Tissue Int





Archive Article

Cover Media Content

Volume : 44 / No. : 1 / Pub. : 2008-01
  1. Correlation Between Dengue Virus Serotype And Humoral Immune Response In Pediatric Dengue Hemorrhagic Fever
  2. Modulation Of Immunoglobulin G (igg) And Cortisol Responses In Breathing Exercise
  3. Prediction Of Distribution Pattern Of Aedes Aegypti As Dhf Main Vector In Jember
  4. Difference Of Interferon Gammalevel (release Assay) In Nurses Exposed To Mycobacterium Tuberculosis And Active Tuberculous Patients
  5. Molecular Expression Of Estrogen Receptor Alpha (erα) And Interleukin 6 (il-6) On Acceleration Of Healing Process Of Long Bone Shaft Fracture By Immediate Repetitive Axial Compression Tension Stabilization (ireact)
  6. Il-4 In Peripheral Blood Mononuclear Cells And Bronchoalveolar Lavage Patients With Pulmonary Tuberculosis Before And After Treatment With Oral Anti-tuberculosis Drugs
  7. Effect Of Oral Curcumin And Immobilization On The Diameter Of Skeletal Muscle Fiber In Rattus Norvegicus
  8. Contralateral Renal Fibroblast And Tubular Cell Apoptosis And Proliferation In Artificial Unilateral Total Urethral Obstruction In Rabbits
  9. Polymorphism C3435t Of The Mdr-1 Gene Predicts Response To Preoperative Chemotherapy In Locally Advanced Breast Cancer With Her2/neu Expression
  10. Review Article:challenge Of Environmental Toxicology In Reformation Era
  11. Bone Morphogenetic Protein 4 (bmp4) And Prostaglandin Alpha (pge2α) Molecular Expression In Healing Process Acceleration Of Long Bone Shaft Fracture Using Immediate Repetitive Axial Compression Tension Stabilization (ireact)
  12. Treatment Response Of Chronic Myelogenic Leukemia In Dr. Soetomo Hospital
  13. Review Article And Clinical Experience:the Obesity Pandemic: The “time-bomb Disease” In The Future?where Have We Been? And What Should We Do?

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