UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 4 / Published : 2008-10

Order : 10, and page :274 - 280

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Original Article :

Pharmacokinetic parameters determination of a single 500-mg oral dose of levofloxacin in healthy subjects by using blood data

Author :

  1. Toetik Aryani*1
  2. Suharjono*2
  3. Febri Hari Murti*3
  1. Department of Clinical Pharmacy, Airlangga University School of Pharmacy
  2. Department of Clinical Pharmacy, Airlangga University School of Pharmacy
  3. Department of Clinical Pharmacy, Airlangga University School of Pharmacy

Abstract :

The pharmacokinetic profiles of once daily oral levofloxacin in seven healthy male volunteers were investigated. The aim of the study was to know how pharmacokinetic parameters and pharmacokinetic profiles in Indonesian healthy subjects receiving a single oral 500-mg dose of levofloxacin. Samples were taken minimally 3 times of the drug‘s half life (which was 24 hours). Blood samples were serially drawn at 0, 0.5, 0.75, 1, 1.25, 1.5, 2, 3, 4, 5, 8,and 24 hours. Plasma levofloxacin concentrations were assayed by spectrofluorometry at excitation wavelength 295 nm and emission wavelength 496 nm. Pharmacokinetic analysis was performed assuming a open two-compartment model. The pharmacokinetic profiles of levofloxacin 500 mg by using blood data such as AUC0-24 were obtained in the range of 52.74- 88.31 mg.hour/L, AUC0-¥ were obtained in the range of 54.41-69.44 mg.hour/L, Cmaks were obtained in the range of 8.60-10.80 mg/L, tmaks were obtained in the range of 0.50-1.25 hour, b were obtained in the range of 0.08-0.14 hour-1, t1/2b were obtained in the range of 5.02-9.06 hour, α were obtained in the range of 0.38-3.16 hour-1, Cl were obtained in the range of 5.66-9.19 L/hour, and Vd were obtained in the range of 64.73-93.84 L.

Keyword :

levofloxacin, pharmacokinetic profile, pharmacokinetic parameters, blood data, Indonesia,


References :

Chambers, HF,(2001) Antimicrobial agent general consideration, in G Joel, Hardman, L Limbird, AG Gilman (eds), Goodman & Gilman’s The Pharmacological Basic of Therapeutics, 10th edn New York : The McGraw-Hill Company, Inc.

Chambers, HF,(2007) Antimicobacterial drugs, in BG Katzung, Basic Clinical Pharmacology San Fransisco : McGraw-hill Company, Inc.

Chambers, HF,(2007) Sulfonamides, trimethoprim & quinolones, in BG Katzung, Basic Clinical Pharmacology San Fransisco : McGraw-hill Company, Inc.





Archive Article

Cover Media Content

Volume : 44 / No. : 4 / Pub. : 2008-10
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  2. Molecular Analysis Of The Coding Sequence Of Mage-1 Gene From Hepatocelular Carcinoma Patient And Testis
  3. Potential Value Of C-reactive Protein As Inflammation Marker And Il-1β, Tnf- As Pro-inflammatory Cytokine On Disease Activity Of Rheumatoid Arthritis
  4. Cell Surface Her2/neu Oncoprotein Expression In Breast Ductal Carcinoma
  5. Difference In The Productivity Of B-lymphocyte Isolated From Lymph Nodes And That Isolated From Mice Spleen In The Production Of Toxocara Cati Monoclonal Antibody Using Hybridoma Technology
  6. Exploration In The Use Of Medicinal Plant Acanthus Ilicifolius L In The Treatment Of Endothelial Dysfunction
  7. Detection Of M. Tuberculosis And Drug Sensitivity Test From Sputum Culture Of Pulmonary Tuberculosis Patients In Dr Soetomo General Hospital Between 2003-2004
  8. The Pharmacokenetics Of Levofloxacin In Healthy Rabbit Treated With Antacid
  9. Potency Of Lactobacillus Reuteri On Reduced Inflammation In Septic Encephalopathy
  10. Pharmacokinetic Parameters Determination Of A Single 500-mg Oral Dose Of Levofloxacin In Healthy Subjects By Using Blood Data
  11. Encephalopathy And Neuroendocrine Disorder In Septic Shock
  12. Osteoarthritic Pain Treatment With Electroacupuncture
  13. Review Article And Clinical Experience: Astaxanthin – Oxidative Stress – Diabetes Mellitus From Basics To Clinics And From General To Specific

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