UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 2 / Published : 2015-04

Order : 4, and page :96 - 100

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Original Article :

Procalcitonin as biomarker of antibiotic effectivity in communityacquired pneumonia

Author :

  1. Ana Khusnul Faizah*1
  2. Winariani*2
  3. Yulistiani*3
  4. Samirah*4
  1. Mahasiswa Fakultas Farmasi
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Farmasi
  4. Dosen Fakultas Farmasi

Abstract :

Major therapy for community-acquired pneumonia (CAP) is antibiotics. Procalcitonin used as the measure of antibioticseffectiveness. Procalcitonin is specific biomarker that elevates in acute bacterial infection. This study aimed to analyze procalcitoninas effective antibiotics biomarker in CAP patients hospitalized at Pulmonology Department Dr. Soetomo Teaching Hospital. Thisstudy was performed by cohort prospective data and analyzed by descriptively. Data were assessed at before antibiotics, day 3 andday 5 after antibiotics therapy. Nineteen community-acquired pneumonia were enrolled. Serum procalcitonin before antibiotictherapy , day 3 and day 5 antibiotics therapy in CAP are 0.51+ 0.19 (0.28-0.89) ng/ml, 0.53+ 0.24 (0.08-0.93) ng/ml and 0.43+ 0.24(0.00-0.83) ng/ml. Serum procalcitonin in CAP with sepsis patients are 0.51+ 0.19 (0.28-0.89) ng/ml (before antibiotic therapy),0.40 + 0.26 (0.08-0.74) ng/ml (day 3) and 0.22 + 0.13 (0.00-0.32) ng/ml (day 5). Serum Procalcitonin in CAP with pulmonary TBare 0.52 + 0.18 (0.38-0.83) ng/ml, 0.55 + 0.25 (0.23-0.89) ng/ml dan 0.57 + 0.16 (0.41-0.82) ng/ml. Serum procalcitonin in CAPwith sepsis and pulmonary TB are 0.55 + 0.12 (0.38-0.70) ng/ml, 0.56 + 0.15 (0.42-0.73) ng/ml dan 0.47 + 0.15 (0.33-0.64) ng/ml.Procalcitonin of 60% CAP with sepsis patients, 20% CAP with pleural effusion patients and no patients of CAP with pulmonary TBreach <0.26 ng/ml. In conclusion, procalcitonin is not useful biomarker in CAP. (FMI 2015;51:96-100)

Keyword :

procalcitonin, community-acquired pneumonia, antibiotic therapy, biomarker,


References :

Carrol ED, Thomson APJ, Hart CA ,(2002) Procalcitonin as a marker of sepsis 20, 1-9 : International Journal of Antimicrobial Agents





Archive Article

Cover Media Content

Volume : 51 / No. : 2 / Pub. : 2015-04
  1. Implementation Of Pharmaceutical Care In Resolving Drug Problems In Type 2 Diabetes Mellitus
  2. Comparison Of The Effect Of Statin Types On The Reduction Of Lipid Profile And Hs-crp Inflammatory Marker In Diabetics With Dyslipidemia
  3. Ciprofloxacin Is Effective In Benign Prostatic Hyperplasia (bph) Patients With Urethral Catheters
  4. Procalcitonin As Biomarker Of Antibiotic Effectivity In Communityacquired Pneumonia
  5. Effect Of Fursultiamine Supplementation On Left Ventricular Ejection Fraction (lvef) In Grade Iii – Iv Heart Failure Patients
  6. Diagnostic Value Of St2 In Patients With Acute Myocardial Infarction
  7. Molecular Analysis Of Rpob Gene Of Mycobacterium Tuberculosis In Patients With Suspected Pulmonary Tuberculosis In Surabaya
  8. Liver Function Tests Of Patients With Dengue Fever, Dengue Hemorrhagic Fever And Dengue Shock Syndrome In Tropic And Infectious Disease Ward In The Department Of Internal Medicine, Dr. Soetomo Hospital, Surabaya
  9. Case Report: Dengue Fever With Perimyocarditis
  10. Correlation Between Heat Shock Protein (hsp) 70 Level And Left Ventricular Dysfunction And Its Effect On Cardiovascular And Rehospitalization Incidence In Patients With Acute Coronary Syndrome
  11. Effect Of Tomato (lycopersicum Commune) Juice On Vaginal Wall Elasticity In Menopausal Rats
  12. Acetosal Resistance In Coronary Artery Disease Between And Within Type 2 Diabetes Mellitus Patients
  13. Immunochromatography Method For Rotavirus Detection Provides Good Accuracy In Diagnosis Of Rotavirus Diarrhea In Children

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