UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 4 / Published : 2014-10

Order : 3, and page :219 - 221

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Original Article :

Relationship between platelet aggregation and hs-crp in patients with pci receiving clopidogrel and aspirin

Author :

  1. Djelang Zainuddin Fickri*1
  2. Siti Sjamsiah*2
  3. Mohammad Yogiarto*3
  1. Clinical Pharmacy Post-graduated Program, Faculty of Pharmacy, Universitas Airlangga
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Kedokteran

Abstract :

Coronary heart disease (CHD) is a progressive disease and is closely related to the inflammatory response and acute thrombosis ofatherosclerotic plaques. Use of loading dose Clopidogrel 300mg and aspirin 200 mg as anti-platelet aggregation reported to haveresponded quite well. Neointimal formation and restenosis are complications that arise in PCI action, triggered by the inflammatoryprocess, IL-6 stimulates release of hsCRP in the liver. hsCRP as an inflammatory marker of cardiovascular events is stillcontroversial. Of the 15 patients with prevalence of 80% male, with main risk factors are dyslipidemia, hypertension and smoking.All patients were found percent aggregation < 80% is included in hypoagregation. This suggests that loading dose Clopidogrel300mg and Aspirin 200 mg is adequate as an anti-platelet aggregation. Seen positive ranks between hsCRP group pre (1.12 ± 1.34)and hsCRP post (2.34 ± 2.03), p = 0.001 (p < 0.05). This suggests that the inflammatory response occurs due to the PCI action. Seennegative correlation between hsCRP and percent aggregation r = -0.16, p = 0.56 (p > 0.05, r < 0.514). The use of Clopidogrel 300mg loading dose and 200 mg aspirin as anti-platelet aggregation is adequate with hypoaggregation response. Identifiedinflammatory response occurs because of PCI with an increase in inflammatory factors hsCRP and no correlation with percentaggregation, so that hsCRP is only referred to as inflammatory factors and not a biomarkers of inflammation and is not is directlylinked to the inflammatory process and reocclusion. (FMI 2014;50:219-221)

Keyword :

hCRP, Platelet Aggregation, Clopidogrel, Aspirin, Percutaneous Coronary Intervention,


References :

von Beckerath N, Taubert D, Pogatsa-Murray G, Schömig E, Kastrati A, Schömig A,(2005) Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial 112, 2946-2950 : Circulation





Archive Article

Cover Media Content

Volume : 50 / No. : 4 / Pub. : 2014-10
  1. Effect Of Touch Therapy On The Growth Of Toddlers (aged 1-3 Years) With Growth Faltering
  2. The Profile Of Genetic Mutation Of The Gyrb Gene On Clinical Isolation Of Acinetobacter Baumannii Resistant To Ciprofloxacin
  3. Relationship Between Platelet Aggregation And Hs-crp In Patients With Pci Receiving Clopidogrel And Aspirin
  4. Correlation Between Preprocedural Hscrp Level And Ck-mb Ratio Pre And Post Percutaneous Coronary Intervention As A Marker Of Preprocedural Myocardial Injury
  5. Evaluation Of Renal Function In Cervix Cancer Patients By Dose Cisplatin 75 Mg/m2 With Nacl-manitol Hydration
  6. Comparison Of Functional Improvement Scale (nihss) Degree Between Acute Intracerebral Hemorrhage Stroke Patients Receiving Standard Treatment And Those Receiving Standard Treatment Plus Celecoxib
  7. Effectiveness Of Kinesio Taping Compared With Short Wave Diathermy On Pain Perception And Functional Status In Knee Osteoarthritis Patients
  8. Cryptosporidium Action In Fecal And Sputum Samples From Patients With Hiv/aids
  9. Percutaneous Transluminal Angioplasty In Patients With Critical Limb Ischemia
  10. Analysis Of Antibiotic Usage In Patients With Bacteremia In The Icu Unit Of Dr. Soetomo Hospital Surabaya
  11. Analysis Of Blood Sample Lysis Rate On Hemoglobin Examination Results Using Rayto Rt. 7600 Auto Hematology Analyzer
  12. Carotid Artery Stenting In A Patient With Transient Ischemic Attack
  13. Risk Factors Of Low Birth Weight (lbw) Incidence. A Case Control Study

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