UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 42 / No. 4 / Published : 2006-10

Order : 9, and page :256 - 263

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Original Article :

Review article: hand deformities in rheumatoid arthritis

Author :

  1. Joewono Soeroso*1
  1. Division of Rheumatology-Department of Internal Medicine Airlangga University School of Medicine -Dr. Soetomo Hospital, Surabaya

Abstract :

RA (rheumatoid arthritis) is a chronic progressive autoimmune disease with a high socio-economic burden. This disease is more common in women compared to men (3:1). Joint involvement occurs early in the natural history of the condition. At the cellular level, the immune system continues to recognize and responds to the autoantigen that leads to persistent activation CD4+ T cells and B cells. Activated B produces rheumatoid factor that lead to the formation of immune complexes in the synovial space, activating complement to stimulate migration of neutrophils into the synovial space. Chemokine production enhances the migration of mononuclear cells into the joint space, adding further to the exudative component of the disease. Proinflammatory cytokines also stimulate the production of collagenases, OPGL (osteoprotegerin ligand), and IL-6. IL-6, IL-18, and other growth factors stimulate fibroblast proliferation, resulting in invasive pannus formation, leading to osteoclast activation and bone destruction. In the final stage, the inflammatory reaction extinguishes and is replaced by fibrosis, which causes tendon adhesions and fixed deformities One of the end results of this pathological inflammation is the disruption of the balance between flexor and extensor tendons, which produces the characteristic hand deformities.

Keyword :

hand deformities, rheumatoid arthritis,


References :

FC Arnett,(1988) The American Rheumatism Association 1987. Revised criteria for the classification of rheumatoid arthritis no info : Arthritis Rheum

SM Edworthy,(1988) The American Rheumatism Association 1987. Revised criteria for the classification of rheumatoid arthritis no info : Arthritis Rheum

DA Bloch,(1988) The American Rheumatism Association 1987. Revised criteria for the classification of rheumatoid arthritis no info : Arthritis Rheum

EHA Choy,(2001) Mechanisms of Disease: Cytokine pathways and joint inflammation in rheumatoid arthritis no info : N Engl J Med

GS Panayi,(2001) Mechanisms of Disease: Cytokine pathways and joint inflammation in rheumatoid arthritis no info : N Engl J Med

M Cutolo,(2000) Recent aspects of gonadal hormone and neurotransmitter interactions with synovial and immune cells: implications in rheumatoid arthritis no info : Ann Rheum Dis

R Straub,(2000) Recent aspects of gonadal hormone and neurotransmitter interactio



Archive Article

Cover Media Content

Volume : 42 / No. : 4 / Pub. : 2006-10
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  2. Effect Of Low Intensity Exercise On Glucose Intolerance In The Depo Medroxyprogesterone Acetate (dmpa) Injected Rat
  3. The Role Of Care, Support And Treatment To Biological Parameters And Clinical Changes Of Plwha In Idicu
  4. The Effect Of Melanin Concentration On Collagen Accumulation In Keloid
  5. The Effects Of Exercise Response On Creatine Kinase In White Wistar Rats
  6. New Paradigm In Oral Focal Infection: Periodontal Disease As An Etiology Of Migraine-anxiety Related Dizziness (mard)
  7. Clinical Manifestation Of Systemic Lupus Erythematosus Mimicking Tuberculosis In A 4 Year-old Child
  8. Case Report: Staphylococcal Scalded Skin Syndrome In A Neonate
  9. Review Article: Hand Deformities In Rheumatoid Arthritis
  10. Review Article: Screening And Management Of Retinopathy Of Prematurity
  11. Review Article And Clinical Experience: Thyroid Storm: A Life-threatening Thyrotoxicosis Therapeutic Clinical Experiences With Formula Ts 41668-24-6

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