UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 2 / Published : 2008-04

Order : 11, and page :115 - 118

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Original Article :

Review article: pathogenesis of repeated abortion in polycystic ovarian syndrome (pcos)

Author :

  1. Arsana Wiyasa IW*1
  1. Department of Obstetrics and Gynecology, Brawijaya University School of Medicine, Syaiful Anwar Hospital, Malang

Abstract :

Early abortion occurs in approximately 15% of all detected pregnancy. However, the actual incidence rate of early abortion is 2-4 times higher in whole pregnancies, either detected or undetected. The causing factors of repeated abortion were uterine anatomy abnormalities (12%-16%), endocrine abnormalities (17%-20%), infection (0.5%-5%), immunological problems (20%-25%), and others (about 10%). Endocrine factor related to the incidence of repeated abortion are luteal phase insufficiency, diabetes mellitus, thyroid disease, and polycystic ovarian syndrome (PCOS). An epidemiological study reported the incidence of repeated abortion among women with PCOS was about 82%. Such higher incidence is related to high level of luteinizing hormone (LH). Another study showed that the pathogenesis of repeated abortion in PCOS was highly complex, not only involving one factor, but it had mutual correlation among several factors. It was suggested that those factors were hyperinsulin, hyperandrogen, and uterine factors.

Keyword :

repeated abortion, polycystic ovarian syndrome, luteininzing hormone, hypersinsulin, hyperandrogen, uterine factors ,


References :

Balen, A,(2001) Hyperscretion of LH: effects and mechanisms, in R Homburg (edn), Polycystic Ovary Syndrome, 1st edn London : Martin Dunitz Ltd

Schust, DJ & Hill, JA ,(2002) Recurrent pregnancy loss, in JS Berek (ed), Novak’s Gynecology, 13th edn Philadelphia : Lippincot William & Wilkins





Archive Article

Cover Media Content

Volume : 44 / No. : 2 / Pub. : 2008-04
  1. Tgf-β1 As The Trigger Of Pulp Fibroblast Proliferation
  2. Difference In Cyclooxygenase-2 (cox-2) Expression Between Low And High Grade Papillary Carcinoma In Human Bladder Cancer
  3. Detection Of Cytokeratin 19 Mrna In Blood As An Early Marker Of Micrometastatic Tumor Cells Of Nasopharyngeal Carcinoma Patients In Surabaya
  4. Pcr Technique Detection Of Chlamydia Trachomatis Dna Band Using Silver Nitrate Staining
  5. Change Of Cd4 Count, Hsp70 And Anti-hsp70 Levels In Hiv Patients
  6. Hiv/aids Prevalence In Surabaya, Indonesia
  7. Treatment Response And Acute Toxicity Evaluation Of 70 Gray Radiation In Nasopharyngeal Carcinoma Patients In Dr Soetomo Hospital, Surabaya
  8. Pharmacodynamic Effects Of Ligustroside Glycoside (a Cns Active Substance) Isolated From Fraxinus Graffithii Clarke Against Chemically Induced Seizures On Mice
  9. Management Of Acute Glomerulonephritis In A Child With Ischemic Stroke And Hypertensive Crisis
  10. Efficacy Of Orlistat Plus Diet Compared To Diet Alone In Reducing Body Weight And Body Mass Index
  11. Review Article: Pathogenesis Of Repeated Abortion In Polycystic Ovarian Syndrome (pcos)
  12. Review Article: Protein Calorie Malnutrition And Immune Response In Children
  13. Review Article And Clinical Experience: Varenicline (champix®) : A Breakthrough For Smoking Cessation Treatment (an α4ß2 Nicotinic Acethylcholine Receptor Partial Agonist)

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