UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 2 / Published : 2008-04

Order : 12, and page :119 - 126

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Original Article :

Review article: protein calorie malnutrition and immune response in children

Author :

  1. Roedi Irawan*1
  1. Department of Child Health, Airlangga University School of Medicine, Dr Soetomo Teaching Hospital, Jl Prof Dr Moestopo 6– 8, Surabaya

Abstract :

The fundamental relationship between malnutrition and immunity was initially described as a thymolymphatic deficiency caused by protein calorie malnutrition (PCM). The selective sensitivity of the thymus to nutritional injury is specifically important in the formative phases of the fetal and neonatal immune system. Recent studies suggest that prenatal nutrition and growth during the first of life may predict thymic function in adolescence. Related studies have shown that prenatal zinc deficiency is associated with decreased immune function in later life. The prenatal zinc deficiency is generally accepted that age related in immune response appear to be seen from programmed involution of the thymus. Thymic involution and induction of thymulin secretion from human thymic epithelial cells have obtained with zinc treatment, suggesting that spe¬cific nutrients may act as regulatory elements by modulat¬ing cellular programs. The potential significance of early nutrition for adaptive immune response in general is also indicated by studies of mucosal immune response to antigens, which have shown that experimental priming at birth ensured both a stronger and a more lasting immune response toward potential pathogens. Malnutrition has an adverse impact on immunological functions and can serve to suppress cell-mediated, humoral, and secretory immune competence. Nutritional immunodeficiencies in human beings appear to respond well to dietary therapy. Micronutrients, trace elements, and vitamins have important regulatory effects on adaptive immune cell function.

Keyword :

malnutrition, immune response,


References :

Beisel, WR,(2000) Interactions between nutrition and infection’, in GT Strickland (ed), Hunter's Tropical Medicine and Emerging Infectious Diseases, 8th edn Philadelphia : WB Saunders

Cunningham, Rundles, S, Cervia, JS,(1996) Malnutrition and host defense, in WA Walker, JB Walkins (eds), Nutrition in Pediair: Basic Science and Clinical Application, 2nd edn London : Marcel Dekker





Archive Article

Cover Media Content

Volume : 44 / No. : 2 / Pub. : 2008-04
  1. Tgf-β1 As The Trigger Of Pulp Fibroblast Proliferation
  2. Difference In Cyclooxygenase-2 (cox-2) Expression Between Low And High Grade Papillary Carcinoma In Human Bladder Cancer
  3. Detection Of Cytokeratin 19 Mrna In Blood As An Early Marker Of Micrometastatic Tumor Cells Of Nasopharyngeal Carcinoma Patients In Surabaya
  4. Pcr Technique Detection Of Chlamydia Trachomatis Dna Band Using Silver Nitrate Staining
  5. Change Of Cd4 Count, Hsp70 And Anti-hsp70 Levels In Hiv Patients
  6. Hiv/aids Prevalence In Surabaya, Indonesia
  7. Treatment Response And Acute Toxicity Evaluation Of 70 Gray Radiation In Nasopharyngeal Carcinoma Patients In Dr Soetomo Hospital, Surabaya
  8. Pharmacodynamic Effects Of Ligustroside Glycoside (a Cns Active Substance) Isolated From Fraxinus Graffithii Clarke Against Chemically Induced Seizures On Mice
  9. Management Of Acute Glomerulonephritis In A Child With Ischemic Stroke And Hypertensive Crisis
  10. Efficacy Of Orlistat Plus Diet Compared To Diet Alone In Reducing Body Weight And Body Mass Index
  11. Review Article: Pathogenesis Of Repeated Abortion In Polycystic Ovarian Syndrome (pcos)
  12. Review Article: Protein Calorie Malnutrition And Immune Response In Children
  13. Review Article And Clinical Experience: Varenicline (champix®) : A Breakthrough For Smoking Cessation Treatment (an α4ß2 Nicotinic Acethylcholine Receptor Partial Agonist)

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