UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 3 / Published : 2014-07

Order : 6, and page :160 - 163

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Original Article :

Soot particulate matter exposure increases interleukin 6 levels in the mechanism of cardiovascular disorders

Author :

  1. Rerdin Julario*1
  2. Muhammad Aminuddin*2
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran

Abstract :

Various mechanisms are thought to play a role in the pathophysiology of cardiovascular disorder, such as systemic and localinflammation, oxidative stress, and endothelial dysfunction. However, the definite cause to cardiovascular disorder is still not knownwith certainty. One of important cytokines that involves in systemic inflammation is IL-6, so this study was to determine whether IL-6increases after exposure to particulate matter in the mechanism of cardiovascular disorders. The objective of this study was toexplain the effects of exposure of soot particulate on IL-6 level in the inflammatory mechanisms of cardiovascular disorder.Experiments were performed on white female rats (Rattus norvegicus) divided into 3 groups: control group (n=10), without exposureto soot particulate; an experiment group 1 (n=15), exposed to soot particulate concentration of 532 mg/m3 one hour/day for 30 days;and an experiment group 2 (n=15), exposed to soot particulate concentration of 1064 mg/m3 one hour/day for 30 days. Measurementof IL-6 plasma level was done by ELISA method performed after the exposure ended. The mean IL-6 levels were increased betweengroups: control, treatment 1 and 2 (P1=38.78 pg/ml + 7.50; 186.83 pg/ml + 110.92), and statistically significant among 3 groups(p=0.000). Statistically significant differences were found between control and treatment 1, control and treatment 2, and treatment 1and treatment 2 (p=0.000). Exposure to soot particulate significantly increased IL-6 levels in experimental animals. Our findingssuggest the role of inflammatory pathways activation in response to soot particulate exposure in the mechanism of cardiovasculardisorders. (FMI 2014;50:160-163)

Keyword :

Soot particulate, IL-6, inflammatory pathways, oxidative stress,


References :

Nazariah SS, Juliana J, Abdah MA,(2013) Interleukin-6 via sputum induction as biomarker of inflammation for indoor particulate matter among primary school children in Klang Valley, Malaysia 5, 93-105 : Glob J Health Sci

Soukup JM and Becker S,(2001) Human alveolar macrophage responses to air pollution particulates are associated with insoluble components of coarse material, including particulate endotoxin 171, 20-26 : Toxicol Appl Pharmacol





Archive Article

Cover Media Content

Volume : 50 / No. : 3 / Pub. : 2014-07
  1. Heavy Metal Contamination May Have A Role In Negative Correlation Between Seafood Consumption And Visuo-motor Development Of 1-3 Year-old Children In Subdistrict Bulak, Surabaya
  2. Detection Of Gyra Gene Mutation Region In Fluoroquinolone Resistant Mycobacterium Tuberculosis Isolate From Surabaya Indonesia
  3. Intravenous Vitamin C Administration Decreases Nitric Oxide Serum Level In Severe Burn Injury
  4. The Overview Of Macrophage, Mast Cell, And Lymphocyte Activity In The Efficacy Distinction Of Pain Reduction For Dry And Wet Cupping Therapies
  5. Effectiveness Of Fosfomycin On Prevention Of Surgical Site Infection Of Closed Brain Injury Patients After Craniotomy In Emergency Unit Dr. Soetomo Hospital
  6. Soot Particulate Matter Exposure Increases Interleukin 6 Levels In The Mechanism Of Cardiovascular Disorders
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  8. Magnesium And Potassium Parenteral Supplementation Does Not Produce Significant Effect On Magnesium And Potassium Serum Level Of Cervical Cancer Patients Receiving Cisplatin Chemotherapy
  9. Effect Of G-csf On Anc Level In All (acute Lymphoblastic Leukemia) Patient With Neutropenia And Febrile Neutropenia During Chemotherapy
  10. Comparative Effectiveness Of Paracetamol And Metamizol As Antipyretics In Patients With Moderate And Severe Brain Injury In Dr. Soetomo Hospital, Surabaya
  11. Analysis Of Complicated Factors Affecting Therapy Effectiveness In Urinary Tract Infections
  12. In Infant With Acute Diarrhea, Nutritional Status Has Correlation With Dehydration Degree, But Not With Mother’s Education And Breastfeeding
  13. The Use Of Antibiotics In Patients With Urinary Tract Infection

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