UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 49 / No. 4 / Published : 2013-10

Order : 2, and page :208 - 215

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Original Article :

The effect of lime peel extract (citrus aurantifolia) to total blood cholesterol levels of mice (mus musculus) that given the high cholesterol diet

Author :

  1. Atika Mira Agniana*1
  2. Maftuchah R*2
  3. Sutji Kuswarini Sunarko*3
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

This article is to review existing research on the effects and potential of lemon peel as anticarcinogenesis. Lime peel containflavonoid. Flavonoids are potent inhibitor of apoB secretion and inhibits the synthesis of cholesterol and triglycveride synthesiswithout affecting LDL receptor activity. Over a period of 35 days, the research used 30 male of mice (Mus musculus) as animal-test.30 samples were divided into five groups with the six miceeach. The first group (control), given regular diet. The second group(negative control), given only high-fat diet. The third group, high-fat diet with ethanolic extract of lime peel 750 mg/kgBW and 0,5%CMC-Na solvent group. The fourth group, high-fat diet with ethanolic extract of lime peel 1500 mg/kgBW and 0,5% CMC-Na solventgroup. The fifth group, high-fat diet with ethanolic extract of lime peel 2250 mg/kgBW and 0,5% CMC-Na solvent group. Totalcholesterol in third group (high-fat diet with ethanolic extract of lime peel 750 mg/kgBW and 0,5% CMC-Na solvent) was higherthan fourth group (high-fat diet with with ethanolic extract of lime peel 1500 mg/kgBW and 0,5% CMC-Na solvent). Totalcholesterol in fifth group (high-fat diet with with ethanolic extract of lime peel 2250 mg/kgBW and 0,5% CMC-Na solven) is thelowest concentration group. According the results of research it can be concluded that the ethanolic extract of lime (Citrusaurantifolia) peel of 750 mg/kgBW, 1500 mg/kgBW, and 2250 mg/kgBW can’t reduce total blood cholesterol of mice (Musmusculu).(FMI 2013;49:208-215)

Keyword :

Lemon peel, Ethanolic extract, Cholesterol, Mice,


References :

Lin Y, Vermeer MA, Bos W, van Buren L, Schuurbiers E, Miret-Catalan S, Trautwein EA,(2011) Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion - : J Agric Food Chem

Yaghmaie P, Parivar K, Haftsavar M,(2011) Effects of Citrus aurantifolia peel essential oil on serum cholesterol levels in Wistar rats - : Journal of Paramedical Sciences





Archive Article

Cover Media Content

Volume : 49 / No. : 4 / Pub. : 2013-10
  1. Relationship Between N-terminal Pro-brain Natriuretic Peptide (nt-probnp) Level And Protein St2 Level In Acute Coronary Syndrome Patient
  2. The Effect Of Lime Peel Extract (citrus Aurantifolia) To Total Blood Cholesterol Levels Of Mice (mus Musculus) That Given The High Cholesterol Diet
  3. Monitoring Of Potassium Level On The Heart Failure Patients Using Captopril And Furosemide
  4. Effect Of Red Yeast Rice (monascus Purpureus) Extract To The Trombopoietin Level In Dengue Infected Patients
  5. Amaranthus Tricolor Linn Preserves The Thickness Of Seminiferous Tubules In Mice (mus Musculus) Induced By Lead Acetate
  6. Effect Of Low Molecular Weight Topical Hyaluronate On White Rat Superficial Wounds Epithelization Treated With Freeze-dried Amnion Membrane
  7. Profile Of Chest And Abdomen Ultrasound On Patients With Dengue Virus Infection In Dr. Soetomo Hospital Surabaya Between February-april 2012
  8. The Prevalence Of Extended Spectrum Beta-lactamase (esbl) In Third Generation Cephalosporin Usage Among Sepsis Patients In The Department Of Internal Medicine Rsud Dr. Soetomo Surabaya
  9. Case Report: Management Of Peptic Ulcer Infection Due To Helicobacter Pylori Infection And Abscess Liver Bowel Perforation
  10. Difference Of Pain Intensity In Tension Type Headache Patients Focusing On The Personality
  11. Hearing Disorder In Multidrug-resistant Tuberculosispatients Atthe Outpatients Unit, Pulmonary Department, Dr. Soetomo Hospital Surabaya
  12. The Difference Of Heart Rate Recovery Among Obese Subjects With And Without Metabolic Syndrome
  13. Dysfunction Of Cochlear And Retrocochlear With Tinnitus In Normal Hearing

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