UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 48 / No. 4 / Published : 2012-10

Order : 8, and page :186 - 189

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Original Article :

The effects of soot particulate exposure on tnf-α expression in the mechanism of cardiovascular disorders

Author :

  1. Suhardi*1
  2. M. Aminuddin*2
  1. -
  2. Dosen Fakultas Kedokteran

Abstract :

Air pollution exposure is related to increased cardiovascular morbidity and mortality. Factors that trigger this event are important for public health, whereas in the mean time epidemiological evidence implicates particulate matter (PM) as a cardiovascular risk factor. Still, the mechanism of this cardiovascular injury is still unclear. Oxidative stress is the main mechanism that explains biological process as a result of PM. On inflammation pathway there will be find increased TNF-a as a response to PM exposure.The aim of this study was to describe the effect of soot particulate exposure on TNF-a expression in mechanism of cardiovascular disorders. Experiments were performed on white female rats (Rattus novergicus) divided into 3 groups: control group (P0) (n=12), without exposure to soot particulate; treatment group 1 (P1) (n=12), exposed to soot particulate concentration of 532 mg/m3one hour/day for 30 days; and treatment group 2 (P2) (n=12), exposed to soot particulate concentration of 1064 mg/m3 one hour/day for 30 days. Immunohistochemical staining was used to quantify the expression of TNF-a in cardiac tissues. We quantified the expression of TNF-a by immunoreactive index score (IRS).Increased TNF-a expression on P2 is more significant (p=0.016) compared to P0. But there’s no significant difference between P0 and P1 (p=0.660), and such with P1 compared to P2 (p=0.81).Exposure to soot particulate significantly increased expression of TNF-a in subjects. Our findings suggest the role of activation inflammatory pathways in response to soot particulate exposure in cardiovascular disorders. (FMI 2012;48:186-189)

Keyword :

soot particulate, TNF-α, inflammatory pathways, oxidative stress,


References :

Araujo JA,(2011) Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis - : Air Qual Atmos Health

Link MS and Dockery DW,(2010) Air pollution and the triggering of cardiac arrhythmias - : Curr Opin Cardiol





Archive Article

Cover Media Content

Volume : 48 / No. : 4 / Pub. : 2012-10
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  2. Oral And Topical Aloe Vera Extract Administration In Diabetic Mice (mus Musculus) Wound Healing Process
  3. Effect Of Combined 500 Mg Vitamin C And 200 Iu Vitamin E On Plasma Malondialdehyde Level After Physical Exercise In Diving Athletes
  4. Antibacterial Activity Of Kunyit (curcuma Longa) Leaves Extract On Staphylococcus Aureus Examined Using Dilution Method
  5. Antibacterial Effect Of Strawberry (fragaria X Ananassa) Extract On Pathogenic Serotype 1-11 Escherichia Coli Revealed Using Dilution Method
  6. Guava (psidium Guajava L.) Juice Is Effective In Lowering Blood Glucose Level In Mice (mus Musculus)
  7. Clinical Profile Of Children With Steroid-sensitive Idiopathic Nephrotic Syndrome Relapsing In The First Year At Dr. Soetomo Hospital, Surabaya
  8. The Effects Of Soot Particulate Exposure On Tnf-α Expression In The Mechanism Of Cardiovascular Disorders
  9. Atomoxetine Therapy Effectiveness In Children With Adhd At Day Care, Dr. Soetomo Hospital, Surabaya
  10. Sweet Star Fruit Reduces Blood Pressure In Normotensive Subjects

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