UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 1 / Published : 2015-01

Order : 2, and page :7 - 12

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Original Article :

The metformin and hyperbaric oxygen therapy on the nuclear factor kappa β (nf-κβ) and fibroblast growth factor (fgf) expression in the wound of hyperglycemic rats

Author :

  1. Bernadette Dian Novita Dewi*1
  2. Wahyu Dewi Tamayanti*2
  1. Faculty of Medicine, Universitas Katolik Widya Mandala
  2. Faculty of Pharmacy, Universitas Katolik Widya Mandala, Surabaya

Abstract :

Complication in diabetes mellitus may occur due to the decline of vasculature resistance and the increased level of oxidative stressmatters that lead to the blockage of fibroblast and collagen formation. This, will eventually prolong the wound healing in diabetesmellitus patient, and is recognized as gangrene. This study, therefore, was conducted to elaborate the outcome of metformin andhyperbaric oxygen (HBO) therapy in accelerating the wound healing of hyperglycemic rats which wound was Pseudomonas sppinoculatedby identifying the nuclear factor kappa B (NF-) and fibroblast growth factor (FGF) expression. In this study, 50 maleWistarrats were used. The rats were grouped into 5 groups, consisted of 2 control groups and 3 treatment groups. The treatmentgroups were administered by aloxan, wounded at the right posterior area, and subcutaneously Pseudomonas spp-inoculated. Somegroups were treated with metformin or combination of metformin- HBO therapy. Collected data was analyzed by KolmogorofSmirnov to evaluate the significant difference of NF-and FGF expression among groups. It was observed that the expression ofNF- and blood glucose were decreased, however the expression of FGF were increased in the group of rats that treated by thecombination of metformin and oxygen hyperbaric (p <0.05). In conclusion, combination of metformin and HBO therapy significantlydecreased the expression of NF- and increased the FGF expression in the wounded areas of male hiperglicemic rats thatPseudomas spp inoculated. Thus, implicated an acceleration of the wound healing process. (FMI 2015;51:7-12)

Keyword :

metformin, hyperbaric oxygen therapy, hyperglycemia, FGF, NF-,


References :

Dewi BDN, Isbandiati E, Guritno ,(2010) Combination of metformin and hyperbaric oxygen therapy increased eNOS concentration 46, 241-246 : Folia Medica Indonesiana

Evans JL, Goldfine ID, Maddux BA, Grodsky GM ,(2003) Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? 52, 1-8 : Diabetes





Archive Article

Cover Media Content

Volume : 51 / No. : 1 / Pub. : 2015-01
  1. Bacterial And Antibiotics Sensitivity Pattern In Neonatal Sepsis Patients
  2. The Metformin And Hyperbaric Oxygen Therapy On The Nuclear Factor Kappa β (nf-κβ) And Fibroblast Growth Factor (fgf) Expression In The Wound Of Hyperglycemic Rats
  3. Bactericidal Effect Of Topical Vitis Vinifera To Methicillin-resistant Staphylococcus Aureus (mrsa) On Rattus Norvegicus Skin Wound
  4. Cardiac Stress Marker Nt-probnp As An Indicator Of Changes In Cardiac Function Post Percutaneous Coronary Intervention
  5. Correlation Between Plasma Nitric Oxide Level And Coronary Artery Stenosis Severity Based On Sullivan Scoring System In Stable Angina Patients
  6. Correlation Between Exclusive Breastfeeding And The Incidence Of Allergy Amongst Children Age ≥ 5 Years Old In The Department Of Paediatric, Dr. Soetomo Hospital, Surabaya
  7. Gastrointestinal Tolerability Of Diclofenac Sodium And Meloxicam In Osteoarthritis Patient
  8. Megadose Methylprednisolone On Total Lymphocyte Count And Disease Activity In Systemic Lupus Erythematosus (sla)
  9. Dexamethasone Study For Prenatal Lung Maturation On Lecithin/sphingomyelin Ratio In Women At Risk Of Preterm Birth
  10. The Use Of Fetal Free Dna As Non-invasive Techniques On Sex Identification
  11. Case Report: Percutaneus And Surgical Transluminal Angioplasty As Complementary Therapies For Leukemic Patients With Acute Limb Ischemic Manifestations
  12. The Correlation Between The Exclusive Breastfeeding For Six Months, Mother's Education Level, Occupation And Kpsp Scores In Children Age 6 To 24 Months
  13. Caffeine May Be Safe Forwhite Male Rats Bone Density

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