UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 40 / No. 4 / Published : 2004-10

Order : 3, and page :150 - 160

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Original Article :

The role of 5α reductase inhibitor (finasteride) in prostate

Author :

  1. Soetojo*1
  1. Department of Urology Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya

Abstract :

This was an experimental study using post-test control group design involving Wistar strain Rattus norvegicus as experimental animals. The objective of this study was to elaborate the action mechanism of finasteride in the prostate. Samples were divided randomly into 2 groups, i.e., 1 month- and 2 month-groups, each comprising 26 rats. Each group was further divided into 2 subgroups, i.e., control and treatment (finasteride) groups, each consisting of 13 rats. After treatment for 1 month and 2 months, the prostate from each rat was removed for TGF ß-1, EGF, and FGF examinations using immunohistochemistry and proliferative degree examination using graticulae. Univariate analysis was used with t-2 sample test since TGF ß-1, EGF, and FGF had no correlation. The analysis showed that finasteride could significantly reduce TGF ß-1, EGF, FGF and proliferation, both in 1 month and 2 monthgroups. Conclusively, this study had successfully elaborated the action mechanism of finasteride in the prostate. It was found that finasteride reduced TGF ß-1, EGF, FGF and proliferation, so that the volume of the prostate was reduced and BPH symptoms relieved. However, the reduction of the TGF ß-1, EGF, FGF and proliferation was not maximal, although it was statistically significant. The author suggests another study in which finasteride and anti-estrogen therapies are applied to prostatic tissue to maximally reduce TGF ß-1, EGF, FGF and proliferation, so that they may restore BPH symptoms.

Keyword :

prostate, BPH, 5α reductase inhibitor (finasteride), TGF ß-1, EGF, FGF and proliferation,


References :

Brooks JD,(2002) Anatomy of the Lower Tract and Male Genitalia. In: Wals PC, Retik AB, Vaughan ED Jr, Wein A (eds), Cambels Urology, 8th edn Philadelpia : WB Saunders

Kirby R, Fitzpatrick, Kirby M, Fitzpatrick A,(1994) Shared Care for Prostatic Diseases Oxford : MSD





Archive Article

Cover Media Content

Volume : 40 / No. : 4 / Pub. : 2004-10
  1. Editorial Vol 40 No 4 2004
  2. Opinion: Science Philosophy And Critical Attitude Of Medical Students
  3. The Role Of 5α Reductase Inhibitor (finasteride) In Prostate
  4. The Effect Of High Frequency (27.11 And 2450 Mhz) Electromagnetic Fields On Immunity Modulation In Mice
  5. Fundal Fluorescein Angiographic Lesion In Age-related Macular Degeneration
  6. Noise Induced Hearing Loss In Steel Factory Workers
  7. Transversal Strength Of Acrylic Resin Plate Repaired By Visible Light Cured And Heat Cured Resin
  8. The Formation Of The Peripheral Retinal Scar Due To Cryoretinopexy In Nonproliferative Diabetic Retinopathy To Maintain The Central Autoregulation Retina System
  9. The Molecular Biology Of Prostate Cancer
  10. Review Article And Clinical Experience: Basic Principles Of Parenteral Nutrition For Diabetic Patients (introduction With Several Empirical Formulas)
  11. Review Article And Clinical Experience: Intractable Epilepsy, From Biomolecular Aspects To Surgical Treatment
  12. Intermittent Exotropia In Aviator Student

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