UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 45 / No. 4 / Published : 2009-10

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Original Article :

Utilization of extract phaleria (phaleria macrocarpa) as a precaution against carbon tetrachloride induced hepatotoxicity in mice

Author :

  1. Reny I\'tishom *1
  2. Rochmah Kurnijasanti*2
  1. Department of Medical Biology Faculty of Medicine, Airlangga University
  2. Department of Medical Biology Faculty of Medicine, Airlangga University

Abstract :

The hepatoprotective activity of extract of mahkota dewa fruit’s (Phaleria macrocarpa) was investigated against Carbon Tetracloride (CCl4) induced hepatic damage. Carbon Tetracloride at a dose of 0,3 ml/kg body weight produced liver damage in mice as manifested by the rise in serum level of Glutamate Pyruvate Transaminase (GPT) and Glutamate Oxaloacetat Transaminase (GOT) to 31.4286 ± 2.4398 and 87.1429 ± 2.4398 respectively, compared to respective control values of 23.0000 ± 1.7889 and 39.0000 ± 3.6968. Pretreatment of mice with mahkota dewa fruit’s extract at concentration of 2.5 ; 5; 10 mg/kg body weigth significantly prevent (p < 0.001) Carbon Tetracloride induced rise in serum enzymes and the estimated values of GPT was 27.2857 ± 1.9760 ; 22.8750 ± 2.1002 and 22.1667 ± 1.3239 respectively, and GOT was 53.0000 ± 8.6410 ; 45.1429 ± 3.4365 and 40.6667 ± 7.1740 respectively. The result indicate that the mahkota dewa fruit’s (Phaleria macrocarpa) extract possesses hepatoprotetective activity which probably related to its antioxidant activity.

Keyword :

Phaleria macrocarpa, hepatotoxic,


References :

David. Z and T.D. Boyer,(1990) Hepatology A texbook of Liver Disease. Biopchemical Tests for Liver Disease. 2nd Ed. - : W.B. Saunders Company

Gitlin. N,(1990) Clinical Aspects of Liver Diseases Caused by Industrial and Environmental Toxins. In (Zakim D. ed) Hepatology Textbook of Liver Disease. 2 nd ed Philadelpia : WB Saunders Company





Archive Article

Cover Media Content

Volume : 45 / No. : 4 / Pub. : 2009-10
  1. Utilization Of Extract Phaleria (phaleria Macrocarpa) As A Precaution Against Carbon Tetrachloride Induced Hepatotoxicity In Mice
  2. Effect Of Transventricular Cerebrospinal Fluid In Patient With Severe Brain Damage With Thin Acute Subdural Bleeding. A Comparative Study With Decompression Trepanation Action
  3. Comparative Effectiveness Between Chlorhexidine Gluconate 0.2% And Povidone-iodine 1% As An Antiseptic To Decrease Density Level Of Intraoral Germs In Maxillofacial Fracture Surgery
  4. Cyclin D1 Expression Relationship With Clinical Stage, Grading Gland Metastasis Of Tumor Cells And Squamous Cell In Cervical Carcinoma
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  9. Macrophage Between The First And Third Day Of Closed Femoral Fracture
  10. Parasitological Examination Of Imported And Indigenous Malaria In Tegalombo Community Health Center, Pacitan Disctrict, East Jawa Province
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