UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Medical Microbiology

ISSN

Vol. 1 / No. 1 / Published : 2012-12

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Original Article :

Comparative antibacterial activity of noni fruit versus ciprofloxacin against salmonalla typhii in vitro

Author :

  1. Riva Satya Radiansyah*1
  2. Juniastuti*2
  3. Sri Purwaningsih*3
  1. Faculty of Medicine, Airlangga University, Surabaya
  2. Department of Microbiology, Faculty of Medicine, Airlangga University, Surabaya
  3. Department of Pharmacology and Pharmacy, Faculty of Medicine, Airlangga University, Surabaya

Abstract :

Typhoid fever is an acute systemic infectious disease caused by Salmonella typhi. Typhoid fever is still a global health problem, especially in developing countries like Indonesia. Indonesia has still showed the high prevalence of typhoid fever. At present, the herbal medicine, noni fruit (Morinda citrifolia) is being frequently used. Noni fruit showed a quite good prospect to be developed in Indonesia. Many studies found that noni fruit consisted of antibacterial compounds such as Ascubin, L. asperuloside, Alizarin, Antraquinon. The purpose of this study was to compare the antibacterial effect of noni extracts and Ciprofloxacin against the growth of Salmonella typhi in vitro. The research was conducted at the Laboratory of Medical Microbiology, School of Medicine, University of Airlangga, in November 2011. First, the noni fruit was dried and then extracted. The extract was diluted serially giving some concentrations as follows : 100%, 50%, 25%, 12,5%, then they were tested to Salmonella typhi by the diffusion method on Muller Hinton Agar, and also to Ciprofloxacin 30 µg as a control. This experiment was replicated three times. The diameter of the inhibition zones shown by the extract and Ciprofloxacin were compared. The diameter of inhibition zones obtained from noni extracts with a concentration 100% to Salmonella typhi ranged 9 - 16 mm (mean 13,33 mm), but those with the other concentrations (50%, 25% and 12,5%) showed no inhibition zone (0 mm). However, Ciprofloxacin showed bigger diameter of inhibition zone than the noni extract, with the average 31,67 mm

Keyword :

noni fruit, Morinda citrifolia, Salmonella typhi, Ciprofloxacin, diffusion method,


References :

Kayne SB,(2009) Complementary and Alternative Medicine, 2nd Edition London : Pharmaceutical Press





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2012-12
  1. Antimicrobial Activity Of Hibiscus Sabdariffa Calyx Extract Against Shigella Dysenteriae In Vitro
  2. Bactericidal Effect Of Cempedak (artocarpus Champeden) Stem Extract On Mycobacterium Tuberculosis
  3. Antibacterial Activity Of Papaya Leaves (carica Papaya,l) Infusum Against Escherichia Coli
  4. Ziehl Neelsen Stain Sensitivity In Determining The Etiologic Of Granulomatous Inflammation
  5. Comparative Antibacterial Activity Of Noni Fruit Versus Ciprofloxacin Against Salmonalla Typhii In Vitro
  6. Susceptibility Pattern Of Mycobacterium Tuberculosis From Bronchoalveolar Lavage (bal) Specimen

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