The Indonesian Journal of Public Health
ISSN 1829-7005
Vol. 10 / No. 1 / Published : 2013-07
Order : 2, and page :12 - 21
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Original Article :
The effect of organophosphate pesticide exposure to cholinesterase enzyme activities and hematological parameters disorders on pesticide sprayers
Author :
- Aditya Sukma*1
- Jojok Mukono*2
- Environmental Health Department, Widyagama Husada Health Science College, Malang
- Dosen Fakultas Kesehatan Masyarakat
Abstract :
ABSTRACT Activities of agriculture is the most absorbing labor sector in Indonesia, Biro Pusat Statistik (BPS) data in the final quarter of 2011 showed approximately 39,328,915 people working in the agricultural sector of about 109 670 399 workforce aged 15 years and above. Organophosphate is the most widely used synthetic pesticide groups in Indonesia. Organophosphorus compound is most commonly associated with poisoning in human; accounting for more than 80% illness is caused by pesticides. In Indonesia, Pelita 3 recorded 1,710 cases of acute poisoning with 9.29% CFR. In the first 3 years of Pelita 4,889 cases of acute poisoning with 8.21% CFR and sub-acute toxicity ranged between 42–50% of those exposed. Measurement of cholinesterase enzyme activity has long been used as main biomarkers in exposure of organophosphate poisoning. Another effect of organophosphate exposure is profile blood disorder which is one of the important components of the health valuation, development of a medication, diagnosis of diseases such as anemia, infectious disease, and blood disorders. The purpose of this study analyzed the effect of organophosphate pesticide exposure on levels of cholinesterase serum and hematology abnormalities parameters on apples plantation sprayer farmer. This was an analytic study design, based on its time used cross-sectional study design. The data was collected by laboratory tests, observation and interviews. The sample selection was done by simple random sampling of 23 exposed and 23 comparisons. The result showed that inappropriate dose (p value = 0.002), frequency of spraying (p value = 0.017) and body position of spraying (p value = 0.001) significantly affected cholinesterase serum levels. Low toxicity (p value = 0.028), moderate toxicity (p value = 0.042) and employment duration (p value = 0.031) significantly affected WBC levels. The conclusion showed that pesticides exposure which affected cholinesterase serum levels and hematology parameters were pesticide dose, frequency of spraying, pesticide toxicity and work duration of one day. There should be a training, advice and guidance regarding good and correct application of pesticides along with farmer’s health check. Keywords: organophosphate, pesticides exposure, cholinesterase serum, hematology parameters, pesticides sprayer
Keyword :
organophosphate, pesticides exposure, cholinesterase serum, hematology parameters, pesticides sprayer,
References :
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Archive Article
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 Volume : 10 / No. : 1 / Pub. : 2013-07 |
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