Journal of Basic Medical Veterinary
ISSN 2302-6820
Vol. 6 / No. 2 / Published : 2017-12
Order : 1, and page :84 - 90
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Original Article :
Critical percentages by adding alcohol 70% toward water in oil cream
Author :
- Wahyu Kusumaning Wardhani*1
- Moch. Lazuardi*2
- Boedi Setiawan*3
- Mahasiswa Fakultas Kedokteran Hewan
- Dosen Fakultas Kedokteran Hewan
- Dosen Fakultas Kedokteran Hewan
Abstract :
This study was conducted to determine the smallest volume of alcohol 70% which can cause water in oil cream unstable. Water in oil cream formulated by dissolving the water phase consisted of distilled water and natrii biboras into the oil phase consisted of parafinnum liquidum and cera alba with temperature 75ºC on water bath. Water in oirl cream divided into tree treatment group, group A with addition of alcohol 70% 0.030 ml, group B with addition of alcohol 70% 0.040 ml and group C with addition of alcohol 70% 0.050 ml. Probit regression analysis obtained 0.034 ml is the smallest volume of alcohol 70% which can cause water in oil cream unstable. Based onorganoleptic observations obtained most stable formulation are group A with characteristic homogeneous white, no rancidity and cracking also soft and oily testure. pH of group A is 8. Based on microscopic observations water phase and oil phase of group A strongly bound.
Keyword :
water in oil, cream, alcohol 70%,
References :
Agral, O,(2013) Formulasi dan Uji Kelayakan Sediaan Krim Anti Inflamasi Getah Tanaman Patah Tulang (Euphorbia tricucalli L.). - : Jurnal Ilmiah Farmasi Universitas Samratulangi
Triakoso, N,(2016) Ilmu Penyakit Dalam Veteriner - : PT. Revka Petra Media Surabaya
Wade, Ainley, and Paul J. Weller,(2000) Handbook of Pharmaceutical Recipients Sixth Edition : American Pharmaceutical Association, Washington
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