UNIVERSITAS AIRLANGGA



Detail Article

Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 6 / No. 1 / Published : 2017-06

Order : 10, and page :63 - 69

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Original Article :

Effect of polygonum minus leaves extract on histopathological features of mice (mus musculus) liver induced by mercuric chloride

Author :

  1. Ribby Ansharieta*1
  2. Thomas Valentinus Widiyatno*2
  3. Rahaju Ernawati*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The aim of this study was to examined the protective effect of Polygonum minus leaves extract on histopathological changes of the liver induced by mercuric chloride in mice (Mus musculus). Thirty male mice were divided into five groups, six mice each and administered through oral gavage with different treatments for 21 days. The treatments were C– (CMC Na 0.5% solution + aquadest), C+ (CMC Na 0.5% solution + 8 mg/kg bw mercuric chloride), T1, T2, and T3 (200, 400, and 800 mg/kg bw Polygonum minus leaves extract respectively + 8 mg/kg bw mercuric chloride). After treatments, histopathological evaluation was done to calculate the percentage of the lesion using Arsad scoring method. The data was analyzed by Kruskal Wallis and Mann-Whitney Test. The research showed significant different (p < 0.05) among the treatment groups. The conclusion of this research is Polygonum minus leaves extract can protect mice liver from destructive effect of mercuric chloride, and the best dose was 400 mg/kg bw

Keyword :

Polygonum minus, mercuric chloride, Mus musculus, liver,


References :

Narasimhulu, G. and Mohamed, J,(2014) Medicinal Phytochemical and Pharmacological Properties of Kesum (Polygonum minus linn.): A Mini Review Vol 6, Issue 4 : International Journal of Pharmacy and Pharmaceutical Sciences

Sigit, S., K. Rachmawati and E. B. Aksono,(2013) Buku Ajar Biokimia Veteriner I - : Airlangga University Press. Surabaya

Triana, L., Nurjazuli and N. Endah,(2012) Analisis Cemaran Logam Berat Merkuri pada Air dan Udang di Sungai Mandor Kecamatan Mandor Kabupaten Landak Vol 11(2): 144-152 : Jurnal Kes Ling





Archive Article

Cover Media Content

Volume : 6 / No. : 1 / Pub. : 2017-06
  1. Effect Of Moringa Oleifera Leaf Extract On The Histopathological Features Liver Cell Of Male Mice (mus Musculus) Exposed By Methylmercury
  2. Effect Of Concentration And Immersion Time In Suspension Of Soursop Seed (annona Muricata Linn) Flour Against Mortality Of Male Rhipicephalus Sanguineus
  3. Effectiveness Of Moringa Oleifera Leaves Ethanolic Extract As A Hepatoprotective Of Mice (mus Musculus) Induced With Methylmercury
  4. Immunomodulator Effect Of Mangosteen (garcinia Mangostana L.) Pericarp Extract On Macrophage Through Expression Of Tlr2 In Newcastle Disease Vaccinated Mice
  5. The Effect Of Eggplant’s (solanum Melongena L) Powder On Serum Level Glutamate Pyruvate Transaminase (sgpt) And Glutamate Oxaloacetate Transaminase (sgot) Of White Rat (rattus Norvegicus) Blood That Given High Fatty Diet
  6. The Anthelmintic Effectiveness Test Of Bitter Melon Fruit (momordica Charantia L.) Ethanol Extract Againts Mecistocirrus Digitatus In Vitro
  7. Helminthiasis Prevalence Of Pigeons (columba Livia) In Surabaya Through Gastrointestinal Tract Surgery
  8. The Effect Of Gadung (dioscorea Hispida Dennst) Tuber Extract Against Culex Fatigans Mosquito Larvae Mortality By In Vitro
  9. The Effect Of Treated Meniran (phyllanthus Niruri Linn) Plant Infusum On Featuring Liver Histopathology Of Aeromonas Hydrophila Infected In Tilapia (oreochromis Niloticus)
  10. Effect Of Polygonum Minus Leaves Extract On Histopathological Features Of Mice (mus Musculus) Liver Induced By Mercuric Chloride
  11. The Influence Of Brucella Abortus Lipopolysaccharide Subunit Vaccine In Adjuvant Montanide Isa 70 Interleukin-2 Production On Sheeps
  12. Critical Percentage’s Pricing Of 0,001n Format Acid Addition To Cream

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