UNIVERSITAS AIRLANGGA



Detail Article

Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 6 / No. 2 / Published : 2017-12

Order : 2, and page :91 - 99

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Original Article :

Protective effect of propolis extract on histopathological features of mice’s (mus musculus) liver induced by lead acetate

Author :

  1. Atlan Panigus Prasetyo *1
  2. Eka Pramyrtha Hestianah *2
  3. Didik Handijatno *3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

This research was conducted to investigate the protective effect of propolis ethanolic extract on the histopathological changes of liver induced by lead acetate in mice (Mus musculus). Twenty-five male mice were divided into five groups and were administered via intubation method or intragastric gavage method with different treatments for 38 days. Negative control group C-  administered with 1.5% of CMC-Na + 0.5% of Tween 80, positive control group C+ administered with 1.5% of CMC-Na + 0.5% of Tween 80 + lead acetate 20 mg/kgBw, T1, T2, and T3 administered with ethanolic extract of propolis 200, 400, and 800 mg/kgBW respectively + lead acetate 20 mg/kgBW. The histopathological changes of liver were examined by using Arsad Scoring method. Then the data was analysed using Kruskal Wallis and continued with Mann-Whitney test. The result showed ethanolic extract of propolis could protect mice’s liver from the damage effect of lead acetate. The best dose of ethanolic extract of propolis on this research was 400 mg/kg bw.

Keyword :

propolis, lead acetate, Mus musculus, liver,


References :

Adikwu, E., O. Deo, O. B. p. Geoffrey and D. A. Enimeya,(2013) Lead Organ and Tissue Toxicity: Roles of Mitigating Agents (Part 1) 4(6): 232-240 : British Journal of Pharmacology and Toxicology

Flora, G., D. Gupta, and A. Tiwari,(2012) Toxicity of Lead : A Reciew with Recent Updates 5 (2): 47-58 : Journal of Interdisciplinary Toxicology

Xianghua, W,(2000) Point Source of Pollution: Local Effects and It’s Control. Industrial Pollution Volume 1 :1-9 : Encyclopedia of Life Support Systems. Beijing. China





Archive Article

Cover Media Content

Volume : 6 / No. : 2 / Pub. : 2017-12
  1. Critical Percentages By Adding Alcohol 70% Toward Water In Oil Cream
  2. Protective Effect Of Propolis Extract On Histopathological Features Of Mice’s (mus Musculus) Liver Induced By Lead Acetate
  3. Most Probable Number Of Escherichia Coli On Beef Of Cattle At Krian Sidoarjo Abattoir
  4. The Effect Of Ginger Juice (zingiber Officinale) On Milkfish (chanos Chanos) Total Bakterial
  5. Analysis Of Helminthiasis On Sumatran Tiger (panthera Tigris Sumatrae) In Gunung Bayan Lestari Zoo At West Kutai District East Borneo
  6. The Influence Of Tomato Paste (lycopersicon Esculentum) Administration Against To The Number Of Leydig Cells Of Mice (mus Musculus) Exposed To Borax
  7. Hepatoprotective Potency Of Tomato Pasta (lycopersicon Esculentum) Against Histopathological Appereance Of Mice (mus Musculus) Liver Exposed To Borax
  8. Effect Different Concentration Of Ethanol Extract Tree Marigold (tithonia Diversifolia (hemls.) A. Gray) Leaves Against Candida Albicans
  9. The Effect Of Spirulina Platensis Extract On Histopatology Of White Male Rats (rattus Norvegicus) In Oxidative Stress
  10. Rat’s Algor Mortis In Room With Ambient Temperature And Room With 20°c Temperature
  11. Pengaruh Pemberian Ekstrak Bawang Bombay (allium Cepa L.) Terhadap Tikus Putih Penderita Diabetes Mellitus
  12. Potential Protection Of Tomato Paste (lycopersicon Esculantum) Against Kidney Histopathologic Picture Of Mice (mus Musculus) Exposed To Borax

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