UNIVERSITAS AIRLANGGA



Detail Article

Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 4 / No. 2 / Published : 2015-12

Order : 1, and page :81 - 87

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Original Article :

The effect of giving vitamin c on endosulfan induced in histopathologic liver of mice (mus musculus)

Author :

  1. Phanjat Mukti Utomo*1
  2. Thomas V. Widiyatno*2
  3. Tutik Juniastuti*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The aim of this research was to determine that effect of vitamin C can decrease the damage of  histopathologic mice liver were induced by Endosulfan. The sample of the research were 20 male mice which three month ages. The number of treatment were four groups P(+), P(-), P1 and P2, each of group was divided into five mice were addopted for seven days. The treatment were given on the 8th days. Group P(+) as a negative control. P(-) were given Endosulfan  doses of 3,2 mg/kg/day for 10 days per oral. P1 were given Endosulfan doses of 3,2 mg/kg/day for 10 days and vitamin C doses of 25 mg/kg/day for 7 days per oral. P2 were given Endosulfan doses of 3,2 mg/kg/day for 10 days and vitamin C doses of 50 mg/kg/day for 7 days per oral. On the 19th day of experimental animals dissected and taken to the liver organ preparations made preparations histopathologis liver of mice. This study used a completely randomized design (CRD), the data obtained were precessed with the Kruskal-wallis test. If there is real difference will be followed by Mann-Whitney test. Statistical analysis using SPSS. The result showed that vitamin C can reduced damage of histopathologic mice liver in degeneration, necrosis and inflamation.  

Keyword :

Endosulfan, Vitamin C, Liver Hispathology, Mice,


References :

Chugh.S.N, Dhawan R, Agarwal N, Mohajan S K,. ,(1998) Endosulfan poisoning in north India, a report of 18 cases. International 36(9); 474-7 : Journal Clin. Pharmacol Ther;





Archive Article

Cover Media Content

Volume : 4 / No. : 2 / Pub. : 2015-12
  1. The Effect Of Giving Vitamin C On Endosulfan Induced In Histopathologic Liver Of Mice (mus Musculus)
  2. Influence Of Hibiscus Sabdariffa L. Calyx On Alveolar Histopathological Feature Of Cigarette Smoke Exposed Mice
  3. The Effect Of L-arginine Orally On The The Histologycal Of Seminiferous Tubules Of Rabbit (oryctolagus Cuniculus) Testicular
  4. Infusum Cincau Green Leaves As The Use Inflammatory Gastric On White Rat (rattus Norvegicus ) Induced Use Caffeine With Inspection Histopathology
  5. The Influence Of Sambiloto Leaf (andrographis Paniculata) Extract As An Imunostimulator Against The Proliferation Of Lymphocyte
  6. Effects Of Plant Wood Yellow Leaf Extract (arcangelisia Flava Merr) As To Prevent Hepatic Dysfunction Examination Levels Of Bilirubin, Sgot Sgpt And Serum Blood On White Rat (rattus Norvegicus)
  7. Activitiy Test Of Snail Mucus (achatina Fulica) On The Healing Level Of Incision Wound Grossly And Microscopically In Batik Python Snake (python Reticulatus)
  8. Prevalence And Degree Of Gastrointestinal Helminth Infections In Cervus Timorensis (blainville 1822) (timor Deer) And Axis-axis (exrl 1788) (axis Deer) In The Pendopo Tulungagung
  9. Antibacterial Activity Of Phyllanthus Niruri L Extract As Substitute Alternative Flumequin Antibiotic To E. Coli On Broiler
  10. The Effects Of Propolis On Histopatological Liver In Male Mice (mus Musculus)
  11. Antibacterial Potential Of Euphorbia Hirta L. Extracts Toward Staphylococcus Aureus Growth Through In Vitro Method
  12. Rosella (hibiscus Sabdariffa Linn) Extract As Hepatoprotector On Lead Poisoning

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