UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Farmasi dan Ilmu Kefarmasian

ISSN

Vol. 1 / No. 1 / Published : 2014-01

Order : 3, and page :10 - 15

Related with : Scholar   Yahoo!   Bing

Original Article :

Pelepasan gentamisin dari pelet bovine-hydroxyapatite-gelatin sebagai sistem penghantaran obat dan pengisi tulang

Author :

  1. Aniek Setiya Budiatin*1
  2. M. Zainuddin*2
  3. Junaidi Khotib*3
  4. Ferdiansyah*4
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi
  4. Instalasi Orthopedi dan Traumatologi RSU Dr Soetomo Surabaya

Abstract :

Polymethyl methacrylate (PMMA) beads releasing antibiotics are used extensively to treat osteomyelitis, but require surgical remove afterwards, because they do not degraded. Hydroxyapatite (HA)-gelatin (GEL) pellet are degradable and compatible compound with osteogenic properties, suitable for use as delivery drug and bone filler was synthesized. The pellet, which avoid bone infection, were exclusively composed with  gentamicin (GEN). The pellet BHA-GEL are synthesized from BHA (20 g), 20 ml GEL 5% and add GEN 10% . Glutaraldehyde as cross-linking agent required to control GEN released for long-time. After implanting the pellet into rabbit femur, we studied: the GEN release, determining the concentration in proximal and distal bone as a function of time, and  bone growth  as consequence of the pellet reactivity in the bone defect. The therapeutic efficacy of  such pellet has been demonstrated in a model of bone defect of the femur in the rabbit. After 28 days the bone defect has been closed by trabecula and osteosit. Gentamicin (GEN) incorporated in composite of HA –GEL has been shown capable of being released over a period of 28 days in concentrations sufficiently high (more than 10 MIC) to control Staphylococcus aureus as nosocomial bacteria.   The BHA-GEL- GEN-GA pellet proved  good form as local antibiotic therapeutic and bone filler. 

Keyword :

BHA, Gelatin, Gentamicin, Glutaraldehyde, Degradable,


References :

Ferdiansyah,(2010) Regenerasi pada Massive Bone Defect dengan Bovine Hydroxyapatite sebagai Scaffold Stem sel Mesensimal, Desertasi Surabaya : Program Pascasarjana Ilmu Kedokteran Universitas Airlangga

Aniek SB., M Zainuddin, Junaidi Khotib,(2014) Biocompatible Composite as Gentamicin Delivery System for Osteomyelitis and Bone Regeneration Surabaya : International Journal of Pharmacy and Pharmaceutical Sciences

Jamel Noor Fatehah,(2011) Studi Penggunaan Antibiotik pada Pasien Bedah Ortopedi Arthroplasti” di SMF Orthopedi dan Traumatologi RSUD Dr Soetomo Surabaya, Skripsi Surabaya : Fakultas Farmasi Universitas Airlangga

Kurdiana Kamiliah Dwi,(2013) Studi Penggunaan Antibiotik pada Pasien Osteomielitis” di SMF Orthopedi dan Traumatologi RSUD Dr Soetomo Surabaya, Skripsi Surabaya : Fakultas Farmasi Universitas Airlangga





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2014-06
  1. Pemberian Informasi Lama Terapi Dan Konfirmasi Informasi Obat Perlu Ditingkatkan Di Puskesmas
  2. Uji Aktivitas Antimalaria Ekstrak Air Daun Johar (cassia Siamea Lamk) Terhadap Plasmodium Berghei Secara In Vivo
  3. Pelepasan Gentamisin Dari Pelet Bovine-hydroxyapatite-gelatin Sebagai Sistem Penghantaran Obat Dan Pengisi Tulang
  4. Aktivitas Antiviral Batang Eucalyptus Globulus Terhadap Virus Hepatitis C Jfh1a
  5. Sintesis Khalkon Dan Derivatnya Menurut Reaksi Kondensasi Claisen Schmidt Dengan Iradiasi Gelombang Mikro
  6. Penentuan Dosis Asam P-metoksisinamat (apms) Sebagai Antiinflamasi Topikal Dan Studi Penetrasi Apms Melalui Kulit Tikus Dengan Dan Tanpa Stratum Korneum
  7. Studi Kelarutan Dan Disolusi Kompleks Inklusi Ketoprofen-hidroksipropil -siklodekstrin (dibuat Dengan Metode Kopresipitasi)

Information index.php/JIPK/JFIK