UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Farmasi dan Ilmu Kefarmasian

ISSN

Vol. 1 / No. 1 / Published : 2014-01

Order : 5, and page :20 - 27

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Original Article :

Sintesis khalkon dan derivatnya menurut reaksi kondensasi claisen schmidt dengan iradiasi gelombang mikro

Author :

  1. Suzana*1
  2. Kholis Amalia*2
  3. Melanny Ika S.*3
  4. Juni Ekowati*4
  5. Marcellino Rudyanto*5
  6. Hadi Poerwono*6
  7. Tutuk Budiati*7
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi
  4. Dosen Fakultas Farmasi
  5. Dosen Fakultas Farmasi
  6. Dosen Fakultas Farmasi
  7. Dosen Fakultas Farmasi

Abstract :

This research has been done synthesis of chalcone and its derivatives  by Claisen Schmidt condensation reaction with microwave irradiation on  400 Watt for 9 minutes using an acid catalyst (bentonite/montmorillonite). The reactions produced chalcone (1,3-diphenyl-2-propen-1-on) and 4- methoxychalcone (1-phenyl-3-(4’-methoxy-phenyl)-2-propen-1-on). Percentage of products were obtained respectively 1.72% and 5.21%. The third compound 2’,4’-dihydroxychalcone  couldnot be synthesized with microwave irradiation using bentonite/montmorillonite as catalyst on 400 Watt for 9 minutes. The reaction products were purified by column chromatography. Purity tests were carried out by thin layer chromatography (TLC) and the melting point test. The observed melting points were 51 oC and 73 oC for chalcone and 4-methoxychalcone. Identification of compounds were carried out by UV-VIS , FT-IR and   1H-NMR spectroscopies.

Keyword :

Synthesis, chalcone, condensation Claisen Schimdt, microwave,


References :

Ameta K, Rathore NS, Kumar B,(2011) Synthesis of some Novel Chalcones and Their Facile One-Pot Convertion to 2-Aminobenzene-1,3-Dicarbonitriles Using Malononitriles - : Ars Docendi Publishing House

Barrette A, Ringwald P,(2010) Global report on Antimalarial drug efficacy and drug resistance: 2000–2010 Geneva : WHO Press

Habibi D, Marvi O,(2006) Montmorillonite KSF and montmorillonite K-10 clays as efficient catalysts for the solventless synthesis of bismaleimides and bisphthalimides using microwave irradiation - : General paper Arkivoc

Kabalka GW, Wang I, Pagni RM,(2001) Potassium fluoride doped alumina : an effective reagent for ester hydrolysis under solvent free conditions - : Green Chemistry

Mavandadi F, Lidstrom P,(2004) Microwave-Asssted Chemistry in Drug Discovery - : Current Topics in Medicinal Chemistry





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2014-06
  1. Pemberian Informasi Lama Terapi Dan Konfirmasi Informasi Obat Perlu Ditingkatkan Di Puskesmas
  2. Uji Aktivitas Antimalaria Ekstrak Air Daun Johar (cassia Siamea Lamk) Terhadap Plasmodium Berghei Secara In Vivo
  3. Pelepasan Gentamisin Dari Pelet Bovine-hydroxyapatite-gelatin Sebagai Sistem Penghantaran Obat Dan Pengisi Tulang
  4. Aktivitas Antiviral Batang Eucalyptus Globulus Terhadap Virus Hepatitis C Jfh1a
  5. Sintesis Khalkon Dan Derivatnya Menurut Reaksi Kondensasi Claisen Schmidt Dengan Iradiasi Gelombang Mikro
  6. Penentuan Dosis Asam P-metoksisinamat (apms) Sebagai Antiinflamasi Topikal Dan Studi Penetrasi Apms Melalui Kulit Tikus Dengan Dan Tanpa Stratum Korneum
  7. Studi Kelarutan Dan Disolusi Kompleks Inklusi Ketoprofen-hidroksipropil -siklodekstrin (dibuat Dengan Metode Kopresipitasi)

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