UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Farmasi dan Ilmu Kefarmasian

ISSN

Vol. 2 / No. 2 / Published : 2015-12

Order : 7, and page :64 - 67

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Original Article :

The effect of anting-anting (acalypha indica linn) extract with malondialdehyde levels of balb/c mice induced streptozotocin

Author :

  1. Martini*1
  2. Yessi Perlitasari*2
  3. Diding Heri Prasetyo*3
  4. Ipop Syarifah*4
  1. Fakultas Kedokteran Universitas Sebelas Maret, Surakarta
  2. Fakultas Kedokteran Universitas Sebelas Maret, Surakarta
  3. Fakultas Kedokteran Universitas Sebelas Maret, Surakarta
  4. Fakultas Kedokteran Universitas Sebelas Maret, Surakarta

Abstract :

Objective: To examine the effect of anting-anting (Acalypha indica Linn) extract with malondialdehyde levels of mice Balb/C induced streptozotocin.   Methode: This study was a laboratory experimental post test only control group design. Diabetes was induced by intraperitoneal streptozotocin doses of 65mg/kg body weight dissolved in 0,02 M citrate saline buffer. The subjects used were 32 male mice divided into 4 groups: (1) Non-diabetic control group; (2) Diabetic group; (3) Treated-diabetic group with metformin doses of 1,3 mg/mice/day and (4) Treated-diabetic group with anting-anting extract dose 1000mg/kg body weight/day. Result: MDA levels of non-diabetic control group 0,211±0,145µmol/L, diabetic group 0,363±0,208µmol/L, treated-diabetic group with metformin 0,389±0,187µmol/L and treated-diabetic group with anting-anting extract 0,309±0,145µmol/L. Conclusion: The experiment result showed that anting-anting (Acalypha indica Linn) extract at dose 1000mg/kg body-weight/day can reduce the MDA levels in Balb/C mice induced streptozotocin but not statistically significan. (p=0,538).

Keyword :

Anting-anting, malondialdehyde, streptozotocin, diabetes mellitus,


References :

Ocktarini R,(2010) Pengaruh Pemberian Ekstrak Herba Anting-anting (Acalypha indica Linn) terhadap Kadar Glukosa Darah Mencit Induksi Streptozotocin Skripsi : Universitas Sebelas Maret

Suherman SK,(2007) Insulin dan Antidiabetik Oral. Dalam : Gunawan SG, Setiabudy R, Nafrialdi (eds). Farmakologi dan Terapi Hal:489-95 : Departemen Farmakologi dan Terapeutik Fakultas Kedokteran Universitas Indonesia

Ahmed RG,(2005) The Physiological and Biochemical Effects on the Balance between Oxidative Stress and Antioxidant Defense System 15:1, 31-42 : Medical Journal of Islamic World Academy of Sciences

Aviles-Santa L, Sinding J, and Raskin P,(1999) Effects of met- formin in patients with poorly controlled, insulin-treated type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial 131:182–8 : Ann Intern Med

Iida KT, Kawakami Y, Suzuki M, Shimani H, Toyoshima H, Sone H, et.al,(2003) Effect of Thiazolidinediones and Metformin on LDL Oxidation and Aortic



Archive Article

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Volume : 2 / No. : 2 / Pub. : 2015-12
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  6. Efek Apoptosis Ekstrak Etanol Ganggang Hijau (ulva Lactuca) Pada Jantung Tikus Yang Diinduksi Isoproterenol
  7. The Effect Of Anting-anting (acalypha Indica Linn) Extract With Malondialdehyde Levels Of Balb/c Mice Induced Streptozotocin

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