Jurnal Ilmiah Biologi FST
ISSN 2303-3428
Vol. 1 / No. 1 / Published : 2013-01
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Original Article :
Uji toksisitas subkronik polisakarida krestin dari ekstrak coriolus versicolor terhadap kadar kreatinin mus musculus
Author :
- Liza Choirun Nisa*1
- Sri puji Astuti Wahyuningsih*2
- Saikhu Akhmad Husen*3
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Abstract :
This study was aimed to determine the effect of polysaccharide krestine of Coriolus versicolor mushroom extract on subchronic toxicity tests on serum creatinine levels of mice (Mus musculus). Twenty four male mice aged 8-10 weeks, weight 25-30 g were used as experimental animals which were divided into four groups (1 controlled group and 3 treatment groups) which consisted of 6 animals for each. The first group was the controlled group (P0) that was given saline 0,1 mL by gavage for 62 days. After that, blood was taken for measuring creatinine level. The data was analized by one way Anova The results showed that the measurement of creatinine levels in the 4 groups obtained P0, P1 and P2 showed a normal creatinine each them is 0,53; 0,73; 0,8 mg/dL whereas on the P3 creatinine levels was 1,067 mg/dL. Giving polysaccharide krestine (PSK) of the extract of C. versicolor on subchronic toxicity test on the dose of 6 mg/kg BB can increase serum creatinine levels of mice.
Keyword :
polysaccharides krestine, Coriolus versicolor, subchronic toxicity tests, creatinine levels.,
References :
Cui, J. and Y. Chisti.,(2003) Polysaccharopeptides of Coriolus versicolor - : Journal of Biotechnology Advances, Hal. 109– 122
Donatus, A. I.,(2001) Toksikologi Dasar Yogyakarta : Fakultas Biofarmasi Universitas Gajahmada,
Hall, R. L,(2007) Clinical pathology of laboratory animals in Animal Model in Toxicology - : 2nd edition, CRC Press, USA, Hal. 789–828
Hidayatulloh, M. dan N. Susilaningsih, ,(2010) Uji Toksisitas Subkronis Ekstrak Valerian (Valeriana officinalis) Terhadap Ginjal Tikus Wistar Semarang : Skrpsi S-1, Fakultas Kedokteran Universitas Diponegoro,
Murtini, J. T., Priyanto, N., dan Siregar, S.T.,(2007) Toksisitas Subkronik Alginat pada Histopatologi Hati, Ginjal dan Lambung Mencit - : Jurnal Bioteknologi Kelautan dan Perikanan, Vol. 5, No. 2
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