UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Oftalmologi Indonesia

ISSN 1693-2587

Vol. 7 / No. 5 / Published : 2011-06

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Original Article :

Histopathologic profile grading of haematoxylene eosin on retinoblastoma stadium

Author :

  1. Hendrian D. Soebagjo*1
  2. Farouk Husein*2
  3. Hari Basuki Notobroto*3
  4. Sutiman B. Sumitro*4
  1. Department of Ophthalmology, Faculty of Medicine, Airlangga University/Dr. Soetomo Hospital Surabaya
  2. Department of Pathology, Faculty of Medicine, Airlangga University/Dr. Soetomo Hospital Surabaya
  3. Faculty of Public Health, Airlangga University
  4. University of Brawijaya, Graduate School of Biology and Bio-Medicine Malan

Abstract :

The purpose of this study was to investigate the morphological features of retinoblastoma with histopathologic aggressiveness on retinoblastoma patients. Retrospective reviewed and analyzed was done according Spearman correlation method. Fiveteen retinoblastoma patients surgical eye specimens were collected and examined at pathology laboratory of Dr. Soetomo Hospital between January 1st, to December 31st, 2010. The patients age average was 47.73 months ± 28.23 months, consist of 60% (9) male and 40% (6) female patients with 93.3% (14) unilateral and 6.7% (1) bilateral. The clinical phenomenas are leucokoria 100% (15), proptosis and chemosis 86.7% (13), optic nerve invasion 50% (6), muscles extraocular invasion 20% (3). exenteration 13 (86.7%), and enucleation 2 (13.3%) . The histopathological features indicated that Rosette cells has been more observed on Flexner-Wintersteiner Rosette 73.3% (11), along with pleomorphic cell 60% (9), necrotic cell 33.3% (5) as well as mitotic cells 60% (9). The tumors usually are poor differentiated 8 (53.3%). Retinoblastoma International Staging was not significanly in association to the tumor differentiation/histopatologicalgrading (rs = -0.170, p = 0.545). However, this study realized that a correlation between the differentiation of retinoblastoma tumor cells with histopathological grading namely in term of the pleumorphic, necrotic and mitotic cell population (α<0.05). 

Keyword :

Retinoblastoma, staging, histopathological grading,


References :

Linn Murphee A,(2005) Intraocular retinoblastoma: The case for a new group classification - : Ophthalmol Clin North Am

Chevez-Barrios P, Eagle RC, Marback EF,(2007) Retinoblastoma: Histopathologic features and prognostic factors. In: Singh AD, Demato BE, Pe’er J Philadelphia : Clinical Ophthalmic Oncology

James SH, Halliday WC, Branson HM,(2010) Trilateral Retinoblatoma, in Radiographics Best Cases from the AFIP - : Afif archives





Archive Article

Cover Media Content

Volume : 7 / No. : 5 / Pub. : 2011-06
  1. Limbal Dermoid And Pre-auricular Tag In A 12 Years Old Girl
  2. Vitrectomy And Silicone Oil Tamponade In The Management Of Retinal Detachment In Marfan Syndrome Patient
  3. Crouzon Syndrome
  4. Histopathologic Profile Grading Of Haematoxylene Eosin On Retinoblastoma Stadium
  5. Decrease Of Corneal Sensitivity In Patients With Diabetes Mellitus Type Ii
  6. Glaucoma Caused Blindness With Its Characteristic In Cipto Mangunkusumo Hospital
  7. Visual Field Abnormality And Quality Of Life Of Patient With Primary Open Angle Glaucoma
  8. The Role Of Ascorbic Acid On Endothelial Cell Damage In Phacoemulsification
  9. The Risk Factors Of Human Papilloma Virus 18 On The Recurrences Of Pterygium
  10. Crouzon Syndrome

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