Jurnal Oftalmologi Indonesia
ISSN 1693-2587
Vol. 7 / No. 4 / Published : 2010-12
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Original Article :
Long-term used of benzalkonium chloridepreservative antiglaucoma eye drops (studies on the expression of matrix-metalloproteinase-1 and tissue inhibitor matrix metalloproteinase-1)
Author :
- Muhammad Ali Faisal*1
- Department of Ophthalmology, Faculty of Medicine Lambung Mangkurat University, Ulin Hospital, Banjarmasin 2
Abstract :
The aim of this study is to compare the mean expression of Matrix metalloproteinase-1 (MMP-1) and the mean expression of TissueInhibitor Matrix metalloproteinase-1 (TIMP-1) from conjunctiva of the long-term preservative antiglaucoma BAC eye drops user with the non-user of preservative antiglaucoma BAC. This cross-sectional study design was held in Dr. Sardjito General Hospital and Dr.Yap Eye Hospital Yogyakarta from November 2009 until August 2010. From the total 32 conjunctival tissue biopsies, 17 samples were derived from the preservative antiglaucoma BAC user group and 15 samples were derived from control conjunctival. The expressionof MMP-1 and TIMP-1 in both groups were detected by immunohistochemistry with monoclonal antibody anti-human MMP-1 andanti-human TIMP-1. The mean expression of MMP-1 from the long terms preservative antiglaucoma eye drops BAC user group was 9.22 ± 8.11% and the expression of TIMP-1 was 2.75 ± 2.36%. In the expression control group, MMP-1 was 1.02 ± 0.71% and the expression of TIMP-1 was 0.46 ± 0.22%. There was a correlation between the number of antiglaucoma drugs used and TIMP-1 expression (r = –0.623) with significancy at 0,008. The expression of MMP-1 and TIMP-1 in the long term preservative antiglaucoma eye drops BAC user group is higher than the expression of the control group with significantly at p < 0.001
Keyword :
Benzalkonium chloride, MMP-1 expression, TIMP-1 expression, conjunctival epithelium,
References :
Noecker RJ, Herrygers LA,(2004) Effect of Preservatives in Chronic Ocular Therapy - : Clinical and Refractive Optometry
Manni G, Centofanti M, Oddone F,(2004) Interleukin-1ß Tear Concentration in Glaucomatous and Ocular Hypertensive Patiens Treated With Preservative-Free Nonselective Beta-Blockers Amerika : Am J Opthalmol
Pisella PJ, Debbasch C, Hamard P, Garcher CC, Rat P, Brignole F, et al.,(2004) Conjungtical Proinflamatory and Proapoptotic Effects of Latanoprost and Preserved and Unpreserved Timolol: An Ex Vivo and In Vitro Study. - : Invest Ophthalmology
Archive Article
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 Volume : 7 / No. : 4 / Pub. : 2010-12 |
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