UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Oftalmologi Indonesia

ISSN 1693-2587

Vol. 7 / No. 3 / Published : 2010-06

Order : 2, and page :91 - 93

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Original Article :

The role of human papilloma virus type 16 in retinoblastoma

Author :

  1. Sri Yuliani Elida*1
  2. Agus Supartoto*2
  3. Angela Nurini Agni*3
  1. Department of Ophthalmology Faculty of Medicine Gadjah Mada University/Dr. Sardjito General Hospital Yogyakarta

Abstract :

The purpose of this study is to observe the role of HPV type 16 in retinoblastoma. This study is a case-control design. The targetpopulations were retinoblastoma patients attending to dr. Yap Eye Hospital and dr. Sardjito General Hospital in Yogyakarta. Thepopulation of concern were patients with unilateral retinoblastoma, bilateral retinoblastoma and patients with non-neoplastic eyediseases. Examinations were performed with Polymerase Chain Reaction (PCR) technique to 17 retinoblastoma preparations and 17non-neoplastic retinal preparations embedded on paraffin blocks. The primary DNA used for this study was SiHa cell line as a positivecontrol. All of the examination toward HPV 16 showed negative result (100%) to both of retinoblastoma group and control group. Factorthat might influence the results was that the retinoblastoma specimens were not a fresh tissue. HPV 16 had no role in retinoblastomain this study. We suggested to do the examination toward DNA of another HPV type in a fresh tissue specimen.

Keyword :

human papilloma virus 16, retinoblastoma, polymerase chain reaction,


References :

Palazzi MA, Yunes JA, Cardinalli IA, Stangenhaus GP, Brandalise SR, Ferreira SA, Sobrinho JSP, Vill,(2003) Detection of Detection of oncogenic Human Papilloma Virus in sporadic retinoblastoma - : Archieves Ophthalmology

Munger Karl, Bruce AW, Nicholas D, Williem CP, Ed Harlow, and Peter MH,(1989) Complex Formation of Human Papillomavirus E7 Proteins with the Retinoblastoma Tumor Supressor Gene Product - : The EMBO Journal

Munoz N, Castellsague X, Gonzales AB,(2006) HPV in the etiology of human cancer Lyon, Institut Catala d’Oncologia. �uai Fulchiron. Lyon, Lyon, France : Institut Catala d’Oncologia.�uai Fulchiron





Archive Article

Cover Media Content

Volume : 7 / No. : 3 / Pub. : 2010-06
  1. Effect Of Genistein On Conjunctival Goblet Cells Density And The Expression Of Interleukin-1bin Ovariectomized Rats
  2. The Relation Of Onset Of Trauma And Visual Acuity On Traumatic Patient
  3. The Role Of Human Papilloma Virus Type 16 In Retinoblastoma
  4. Ocular Survival Rate Penderita Retinoblastoma Yang Telah Dilakukan Enukleasi Atau Eksenterasi Di Rsud Dr. Soetomo Surabaya
  5. Human Papilloma Virus In Progressive Pterygium And Stationary Pterygium
  6. Perbandingan Ekspresi P53 Pada Pterigium Primer Progresif Setelah Pemberian Injeksi Subkonjungtiva Dengan Mitomicin C Dan 5 Fluorourasil
  7. Effect Of Genistein On Conjunctival Goblet Cells Density And The Expression Of Interleukin-1b In Ovariectomized Rats
  8. Management Of Upper Eyelid Coloboma With Three Steps Technique Surgery
  9. Ptotic Management In Marcus Gunn Jaw-winking Syndrome
  10. The Caterpillars Eat One Eye On The Pseudo Lymphoma Tumor
  11. The Untreatable Case Of Retinopathy Of Prematurity Grade V

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