UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Oftalmologi Indonesia

ISSN 1693-2587

Vol. 7 / No. 4 / Published : 2010-12

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Original Article :

Visual acuity of methanol intoxicated patiens before and after hemodialysis, methylprednisolone and prednisone therapy

Author :

  1. AA Mas Putrawati Triningrat*1
  2. Ni Made Kartika Rahayu*2
  3. IB Putra Manuaba*3
  1. Department of Ophthalmology Faculty of Medicine Udayana University/Sanglah General Hospital, Bali
  2. Department of Ophthalmology Faculty of Medicine Udayana University/Sanglah General Hospital, Bali
  3. Faculty of Mathematic and Basic Science, Udayana University, Bali

Abstract :

Methanol intoxication is intoxication because of methanol comsumption causing simmetrical optic neuropathy, metabolic acidosis and death. The mechanism of methanol toxicity has closely been linked to the effect of formic acid from methanol by alcohol dehydrogenase. The aim of this study is to investigate the relationship of visual acuity in methanol intoxication before and after hemodialysis, methylprednisolone and prednisone therapy. This study was a retrospective descriptive study to sixteen subjects. Each subject was treated with hemodialysis and methylprednisolone 1000 mg/day intravenous for three days, continued with prednisone 1mg/kgbw/dayfor 11 days. Visual acuity and optic nerve were observed on the first, second, third, and seventh day. The larger proportion were males (94%). The mean age was 28.8 ± 8.7 years. The onset to hospital was 29.2 ± 13.3 hours after methanol intoxication. Visual acuity at the first hospitalized was 1.42 ± 0.36 logMAR on the right eye and 1.45 ± 0.37 logMAR on the left one and blood pH was 7.18 ± 0.06. Optic nerve was hyperemia. Started from the second day of therapy, significant change on visual acuity was on right (p = 0.004; p = 0.001, p = 0.001 Wilcoxon test ) and the left eye (p = 0.004; p = 0.002; p = 0.001; Wilcoxon test). No significant change in optic nerve was found. A significant visual acuity improvement is found after hemodialysis, methylprednisolone and prednisone therapy. The optic nerve is hiperemia, and bilateral simetric.

Keyword :

Methanol intoxication, toxic optic neuropathy, hemodialysis, methylprednisolone, prednisone,


References :

Kraut JA, Krautz I,(2008) Toxic alcohol ingestion: Clinical feature, diagnosis, and management Nephrol : Clin J Am Soe

Chan JW,(2007) Nutritional and toxic optic neuropathy. Optic nerve disoroder diagnosis and management - : Kentucky: Spinger

Epker JL, Bakker J,(0000) Case report: Accidental methanol ingestion - : BMC Emergency Medicine

Lin ES BT, Lai E, Oh TE,(1989) A case of severe methanol intoxication Hongkong : Journal of the Hong Kong Medical Association

Arora V NI,(2006) Bilateral putamina necrosis cause by methanol intoxication india : Indian J Radio Imaging





Archive Article

Cover Media Content

Volume : 7 / No. : 4 / Pub. : 2010-12
  1. Visual Acuity Of Methanol Intoxicated Patiens Before And After Hemodialysis, Methylprednisolone And Prednisone Therapy
  2. Cutler Beard Technique For The Management Of Superior Palpebra Sebaceous Adenocarcinoma
  3. Long-term Used Of Benzalkonium Chloridepreservative Antiglaucoma Eye Drops (studies On The Expression Of Matrix-metalloproteinase-1 And Tissue Inhibitor Matrix Metalloproteinase-1)
  4. The Profile Of Tear Mucin Layer And Impression Cytology In Pterygium Patients
  5. Constraints And Supporting Factors To Access Free Cataract Surgery
  6. Correlation Between Blood Glucose Level And Hba1 C With Lens Thickness In Type 2 Diabetes Mellitus Patients
  7. Traumatic Globe Subluxation
  8. Awareness Of Subconjunctival Bleeding On Warfarin Therapy Patient
  9. Bilateral Optic Neuritis In Children Due To Multiple Sclerosis
  10. Bilateral Optic Neuritis In Children Due To Multiple Sclerosis

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