Jurnal Penelitian Medika Eksakta
ISSN 1411-6626
Vol. 8 / No. 3 / Published : 2009-12
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Original Article :
Consentration il-1 and gustducin changing to bitter taste on fever
Author :
- Jenny Sunariani*1
- Fakultas Kedokteran Gigi Universitas Airlangga
Abstract :
ABSTARCT Homeostatic changes in the body, such as fever caused inflammation,wich impact a sense of bitterness inside mouth. It implies in the reduction of appetite, which may finally result in the reduction of physical condition due to inadequacy of food intake. It causes the inhibition of healing process, which reduces working productivity. The objective of this study was to identify the mechanism of bitterness due inflammation, as proved locally in the taste buds of Wistar rats. This study was carried out experimentally using post-only control design in experimental animals of male Wistar strain Rattus norvegicus. The animals were divided into two groups. First group as control, while the second group received treatment with Salmonella typhimurium 0.5 mUkgBW. Blood sample and tongue incision were taken from the animals. IL-1 was counted, and tongue incision was used for and immunohisfochemical staining for the variables Gusfducinc. Data were analyzed using Kolmogorov-Smirnov test for data normality, and Comparative test. The discriminant analysis was also done to find the discriminant variable. From the result, it was found that there was an increase of biological response of signaling transduction of bitterness in taste buds, as indicated from the increase of these variables, Gustducin. in treatment group or in inflammatory fever condition as compared to control group (p
Keyword :
inflammation, taste buds, Gustducin, IL-1,
References :
Archive Article
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 Volume : 8 / No. : 3 / Pub. : 2009-12 |
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