UNIVERSITAS AIRLANGGA



Detail Article

Kesehatan Lingkungan

ISSN 1829-7285

Vol. 4 / No. 2 / Published : 2008-01

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Original Article :

Free radical formation interference from circadian rhythm disorder and coal dust exposure

Author :

  1. Qomariyatus Sholihah*1
  2. M. Aris Widodo*2
  1. Program Studi Kesehatan Masyarakat Fakultas Kedokteran Universitas Lambung Mangkurat Banjarbaru
  2. Fakultas Kedokteran Universitas Brawijaya Malang

Abstract :

Circadian rhythm is a bological clock that regulate physiological function and human behaviour. Melatonin is an agent which is effected and regulated by circadian rhythm through photoreceptor activity. Melatonin roles passively in immune system by mediating antioxidant and metabolites matters activation which are scavenging ROS. Melatonin roles actively as immunomodulator that stimulate the production of progenitor granulocyte-macrophage cells, NK cells, CD4+ cells, cytokines of NK and lymphocyte T-helper cells, but inhibits production and release of CD8+ cells. On the other sides, coals crushing process into particles produce radical hydroxil at new coal surface. PM2,5-10 coal particles category cause inflammation in broncho-tracheal area, whereas PM≤ 2,5 category cause inflammation in alveolar area. These inflammation activate alveolar macrophage in order to release cytokines like IL-1, IL-6, IL-8 and TNF.

Keyword :

circadian rhythm disorder, melatonin, coal, particles, ROS,


References :

Barnes PJ,(2004) Mediators of chronic obstructive pulmonary disease. - : Pharmacol Rev 56:515-548

Becker S, Dailey LA, Soukup JM, Grambow SC, Devlin RB, Huang YT,(2005) Seasonal Variations in Air Pollution Particle Induced Inflammatory Mediator Release and Oxidative Stress - : Environ Health Perspect 113:1032–1038.

Grivas TB, Savvidou OD,(2007) Melatonin the "light of night" in human biology and adolescent idiopathic scoliosis - : Scoliosis 2 (6): 1-14.

Hardeland R, Pandi Perumal SR,(2005) Melatonin, a potent agent in antioxidative defense: Actions as a natural food constituent, gastrointestinal factor, drug and prodrug. - : Nutrition & Metabolism 2:22.

Huang C, Li J, Zhang Q, Huang X,(2002) Role of bioavailable iron in coal dust-induced activation of activator protein-1 and nuclear factor of activated T cells. - : Am J Respir Crit Care Med 27:568-574.





Archive Article

Cover Media Content

Volume : 4 / No. : 2 / Pub. : 2008-01
  1. Hazard Analysis And Critical Control Point (haccp) In Food Managing Of Hospital Patient At Lumajang Islamic Hospital
  2. Number Of Patients And Medical Solid Waste Production In Hospitalization And Emergency Room Of Siti Khadijah Hospital, Sepanjang Sidoarjo
  3. The Correlation Of Distance Waste Disposal To Water Chemical Quality In Fishpond And Health Disorder Of Fishpond’s Consumer Around Waste Landfills Benowo
  4. The Correlation Of The Leachate Benowo Landfills Pollution To Level Hg In The Fish And The Consumer Health Effect
  5. Correlation Between Leachate Lead (pb) Levels At Salt Pond Around Benowo Landfill Toward Lead Level In Hair Of Salt Consumer
  6. Environmental Factor On Endemic Area Of Malaria In Border Area
  7. Coal Dust Exposure And Respiratory Disorders Among Coal Stockpile’s Field Workers
  8. Hygiene And Sanitation Of “nasi Tempe Penyet” At Karangmenjangan Street Vendors, Surabaya
  9. Free Radical Formation Interference From Circadian Rhythm Disorder And Coal Dust Exposure
  10. Hygiene And Sanitation Of Refill Drinking Water Depo At Tanjung Redep, Berau, East Borneo

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