UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 11 / No. 2 / Published : 2016-09

Order : 6, and page :80 - 83

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Original Article :

Administration of sembukan’s leaves extract improve blood glucose level in diabetes mellitus animal model

Author :

  1. Steven Christian Susianto*1
  2. Yuani Setiawati*2
  3. Raden Argarini*3
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Introduction: Paederia foetida contains iridoid glycosides which has anti hyperglycemic effect. Purpose: The purpose of this study was to know the effect of sembukan’s leaves extract administration to blood glucose level decrement in diabetes mellitus animal model and compared it to glibenclamide. Method: This research was a experimental laboratory which separated post test only group design. The subjects were 25 male mice (Mus musculus) aged 3 months with the average of 28.8±4.2 g in weight and were divided into 5 groups, control group K2,K3,K4,5 subsequently given 10 mg/kgBW glibenclamide, 125 mg/kgBW, 250 mg/kgBW and 500 mg/kgBW sembukan’s leaves extract . Subjects were inducted with 40 mg/kgBW streptozotocin for 5 days. 2 hours after the treatment, oral glucose tolerance was done. Data were processed using One Way Annova and LSD testing with SPSS program 20. Result: The result of the research showed that Paederia foetida 125 mg/kgBW gives the highest effect in decreasing the blood glucose level compared to the 250 mg/kgBW and 500 mg/kgBW and higher compared to glibenclamide (p=0.026). Conslusion: In conclusion, sembukan’s leaf extract could decrease blood glucose level in diabetes mellitus’s animal with the best decrement potential on 125 mg/kgBW and still higher compared to the glibenclamide.

Keyword :

Diabetes Mellitus, Streptozotocin, Paederia foetida, Blood glucose level,


References :

Kapadia,(1979) Revised structure of paederoside, a novel monoterpene S-methyl thio carbonate Vol. 22:1937-1938 : Tetrahedron letters

Arief,(2006) Tumbuhan Obat dan Khasiatnya. Seri 3 Hal. 60-63 : Jakarta: Swadaya





Archive Article

Cover Media Content

Volume : 11 / No. : 2 / Pub. : 2016-09
  1. A Function Discriminate The Risk Of Type 2 Diabetes Among Indonesian Obese Characteristics
  2. Dynamic Eccentric Exercise Improve Glut-1 Expression On Calf Muscle Of Diabetic Mice Models
  3. Effects Of Tumeric Ethanol Extract (curcuma Domestica Val) To Prevent Ulcus Pepticum Which Induced By Histamin
  4. Effect Of Caffeine On Endurance Duration Of Student Using Graded Exercise Test
  5. Effects Of Glutathione Protection Against Erythrocytes Post Submaximal Physical Exercise On Rat (rattus Norvegicus) Males
  6. Administration Of Sembukan’s Leaves Extract Improve Blood Glucose Level In Diabetes Mellitus Animal Model
  7. Supplementation Of Saturated Fatty Acid, Mono Unsaturated Fatty Acid, And Poly Unsaturated Fatty Acid: Triglyceride Comparison Study On White Rat (rattus Norvegicus)
  8. Comparison Of Lumbar Flexibility And Hamstring Muscles Shortening In Full Day And Non Full Day Students
  9. Correlation Between Body Mass Index With Physical Fitness Student Of Airlangga University
  10. The Effects Of Interval Training On Slowing Of Weight Gain And Lowering Lee Index Scoring In An Obese Rats Model

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