UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 11 / No. 2 / Published : 2016-09

Order : 5, and page :77 - 79

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Original Article :

Effects of glutathione protection against erythrocytes post submaximal physical exercise on rat (rattus norvegicus) males

Author :

  1. Afan Abdul Jabbar*1
  2. Raden Argarini*2
  3. Choesnan Effendi*3
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Submaximal physical activity can produce free radicals that cause reduction of the erythrocytes through the cell membrane integrity damage. Glutathione has antioxidant effects that can protect cells from free radicals due to heavy physical activity. The purpose of this study was to determine whether exogenous glutathione had an effect on the improvement of erythrocytes. This study was an experimental study using separate post test only control group design. The subjects used were 28 males of Rattus norvegicus strain wistar. Subjects were divided into four groups with different treatment. (K1): control group, (K2): a group with a placebo injection, (K3): group with glutathione injection of 54mg / kg, (K4): group with glutathione injection of 108mg / kg. K1, K2, and K3 also got exercise treatment up to 90% of maximum exercise time before injection. Glutathione was given by intraperitoneal. Methods of data analysis used ANOVA in SPSS 16th program. Results of the study were obtained decreasing in the number of erythrocytes (p=0,010) and haemoglobine levels (p=0,000) at submaximal physical exercise (K2). At K3 the effect of repairs red cell count (p=0.025) and hemoglobin (p=0.013) was obtained. In K4 the effect of repairs red cell count (p=0.714) and hemoglobin (p=0.551) was obtained. Conclusion of this study was the glutathione could prevent damage to the red blood cells in Rattus norvegicus and can restore the number of erythrocytes and haemoglobin approached to the normal values.

Keyword :

Submaximal physical exercise, Free radical, Glutathione, Erythrocyte, Haemoglobine,


References :

Aslan, R,(1996) Effect of Acute and Regular Exercise on Antioxidative Enzymes, Tissue Damage Markers and Membrane Lipid Peroxidation of Erythrocytes in Sedentary Students Tr Issue 28, pp. 411-414 : J. of Medical Sciences





Archive Article

Cover Media Content

Volume : 11 / No. : 2 / Pub. : 2016-09
  1. A Function Discriminate The Risk Of Type 2 Diabetes Among Indonesian Obese Characteristics
  2. Dynamic Eccentric Exercise Improve Glut-1 Expression On Calf Muscle Of Diabetic Mice Models
  3. Effects Of Tumeric Ethanol Extract (curcuma Domestica Val) To Prevent Ulcus Pepticum Which Induced By Histamin
  4. Effect Of Caffeine On Endurance Duration Of Student Using Graded Exercise Test
  5. Effects Of Glutathione Protection Against Erythrocytes Post Submaximal Physical Exercise On Rat (rattus Norvegicus) Males
  6. Administration Of Sembukan’s Leaves Extract Improve Blood Glucose Level In Diabetes Mellitus Animal Model
  7. Supplementation Of Saturated Fatty Acid, Mono Unsaturated Fatty Acid, And Poly Unsaturated Fatty Acid: Triglyceride Comparison Study On White Rat (rattus Norvegicus)
  8. Comparison Of Lumbar Flexibility And Hamstring Muscles Shortening In Full Day And Non Full Day Students
  9. Correlation Between Body Mass Index With Physical Fitness Student Of Airlangga University
  10. The Effects Of Interval Training On Slowing Of Weight Gain And Lowering Lee Index Scoring In An Obese Rats Model

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