UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 5 / No. 3 / Published : 2006-06

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Original Article :

Peran aquaporin-2 dalam transport air di ginjal

Author :

  1. Indri N Rahayu*1
  2. Harjanto -*2

Abstract :

Since the discovery of the aquaporins ten years ago, researches around the world have sought to learn how these proteins work. In the kidney aquaporin-2 (AQP2) provides a target for hormonal regulation of water transport by vasopressin. Short-term control of water permeability occurs via vesicular trafficking of AQP2 and long-term control through changes in the abundance of AQP2 water channels. Defective AQP2 trafficking causes nephrogenic diabetes insipidus, a condition characterized by the kidney inability to produce concentrated urine. AQP2 is redistributed to the apical membrane of collecting duct cells through activation of a cAMP signaling cascade initiated by the binding of vasopressin to its V2-receptor. Protein kinase A-mediated phosphorylation of AQP2 has been proposed to be essential in regulating AQP2-containing vesicle exocytosis. Cessation of the stimulus is followed by endocytosis of the AQP2 proteins exposed on the plasma membrane and their recycling to the original stores.

Keyword :

Water channel, aquaporin-2 (AQP2), water transport, vasopressin (VP),


References :

P Agre,(2000) Aquaporin Water Channel in Kidney - : Am J Soc Nephrol 11

P Agre,(2002) Aquaporin Water Channels – from atomic structure to clinical medicine. - : J. Physiol 542.1

LS King,(2002) Aquaporin Water Channels – from atomic structure to clinical medicine. - : J. Physiol 542.1

M Yasui,(2002) Aquaporin Water Channels – from atomic structure to clinical medicine. - : J. Physiol 542.1

WB Guggino,(2002) Aquaporin Water Channels – from atomic structure to clinical medicine. - : J. Physiol 542.1

OP Ottersen,(2002) Aquaporin Water Channels – from atomic structure to clinical medicine. - : J. Physiol 542.1

Y Fujiyoshi,(2002) Aquaporin Water Channels – from atomic structure to clinical medicine. - : J. Physiol 542.1

A Engel,(2002) Aquaporin Water Channels – from atomic structure to clinical medicine. - : J. Physiol 542.1

Nielsen,(2002) Aquaporin Water Channels – from atomic structure to clinical medicine. - : J. Physiol 5



Archive Article

Cover Media Content

Volume : 5 / No. : 3 / Pub. : 2006-06
  1. Kandidat Bahan Imunokontrasepsi Protein Gzp3 Tidak Mempengaruhi Fungsi Fisiologis Siklus Birahi Hewan Coba Model
  2. Pengaruh Olahraga Teratur Dan Terukur Terhadap Kadar Hormon Estrogen Serum Wanita Pascamenopause
  3. Peran Aquaporin-2 Dalam Transport Air Di Ginjal
  4. Peran Molekul Adhesi Pada Proses Ekstravasasi Netrofil
  5. Pengaruh Masa Kerja Dalam Lingkungan Bising Terhadap Perbedaan Nilai Ambang Pendengaran Pekerja Unit Tenun Pt Pandatex Magelang
  6. Effect Of Low Intensity Exercise On Glucose Intolerance In The Depo Medroxyprogesterone Acetate (dmpa) Injected Rat
  7. Pengaruh Latihan Renang Intensitas Ringan Dan Berat Terhadap Panjang Tulang, Tinggi Dan Jumlah Sel Kondrosit Lempeng Epifise Tibia Tikus Putihjantan Usia Pertumbuhan

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