UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 7 / No. 2 / Published : 2008-02

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Original Article :

Peran endocannabinoid dalam pengaturan nafsu makan

Author :

  1. Rd Argarini*1
  2. Choesnan Effendi*2
  1. Departemen Ilmu Faal, Fakultas Kedokteran Universitas Airlangga
    Jl. Prof. DR. Moestopo No.47
  2. Departemen Ilmu Faal, Fakultas Kedokteran Universitas Airlangga
    Jl. Prof. DR. Moestopo No.47

Abstract :

Physiological basis for the actions of plant-derived cannabinoids has been explained by the discovery of two cannabinoid receptors and their endogenous ligands, the endocannabinoids. These substances include anandamide, 2-arachidonoyl glycerol (2-AG), noladin ether, NADA, and virodhamine. The endocannabinoids-cannabinoid receptor (ECBR) system influences energy balance and food intake at four different levels: hedonic evaluation at the limbic system level, modulation integrative functions of feeding behaviour within the hypotalamus and hindbrain and, peripherally, in the intestinal system and adipose tissue. The drugs significantly increase intake, elevated hunger ratings and enhanced food appreciation. Clinically, THC (dronabinol) which is psychoactive compound of cannabinoids used to combat a reduction in appetite and consequent weight reduction and wasting, whereas the antagonist receptor of cannabinoid 1 (CB1 receptor), rimonabant used to reduce food intake and adiposity in patient with obesity

Keyword :

appetite, endocannabinoids, hypothalamus,


References :





Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2008-02
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  2. Penggunaan Antikanker Sari Buah Merah (pandanus Conoideus) Terhadap Kultur Sel Mieloma
  3. Tingkat Serapan Hara Dan Produksi Tanaman Kentang Dan Tomat Sebagai Respon Terhadap Pupuk Hayati
  4. Uji Spesifisitas Protein Prolaktin Dari Serum Darah Itik Molting Melalui Metode Western Blot
  5. Pengaruh Pemberian Kafein Terhadap Penghematan Glikogen Otot Pada Latihan Submaksimal
  6. Rasio Netrofil,limfosit (n Or L) Sebagai Indikator Stres Pada Owa Jawa (hylobates Moloch Audebert 1797) Di Tempat Penangkaran
  7. Potensi Capping Phenomena Dalam Analisis Asosiasi Hla Dengan Diabetes Mellitus Tipe 2
  8. Peran Endocannabinoid Dalam Pengaturan Nafsu Makan
  9. Apoptosis: Melalui Mekanismenya Menjadikan Dasar Strategi Terapi
  10. Peran Peptida Yy Pada Regulasi Homeostasis Energi
  11. Potensi Melatonin Secara Fotoneuroendokrin Sebagai Antioksidan Alamiah
  12. Studi Shp Dan Protein Stat Pada Transduksi Signal Hormon Pertumbuhan (growth Hormone) Dengan Teknik Blotting

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