UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 7 / No. 1 / Published : 2007-10

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Original Article :

Peran l-karnitin dalam memfasilitasi β-oksidasi di mitokondria

Author :

  1. Purwo Sri Rejeki*1
  1. Departemen Faal Fakultas Kedokteran Universitas Airlangga
    Jl. Mayjen Prof. Dr. Moestopo No. 47 Surabaya 60132 Indonesia

Abstract :

The -oxidation of long chain fatty acids is central to provision of energy for the organism and is of particular importance for cardiac and skeletal muscle. Long chain fatty acids are -oxidized by a peroxisomal and mitochondrial pathway, but peroxisomal pathway is quantitavely minor. L-carnitine is an essential cofactor in fat metabolism. Three carnitine transporters have been identified: organic cation transporter Na-1 (OCTN1), OCTN2, and OCTN3 that uptake L-carnitine from extracellular fluids. L-carnitine affect transport of fatty acid moieties into mitochondrial matrix as a functional component of pathway. Long chain fatty acids are transported into the mitochondrial matrix by a complicated mechanism which depends on the availability of carnitine. L-Carnitine serves two major functions. It is best known for its role in facilitating entry of long-chain fatty acids into mitochondria for utilization in energy-generating processes. L-Carnitine also facilitates removal from mitochondria of short-chain and medium-chain fatty acids that accumulate as a result of normal and abnormal metabolism.

Keyword :

L-Carnitine, -oxidation, mitochondria,


References :





Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2007-10
  1. Perubahan Kadar Laktat Darah Akibat Manipulasi Sport Massage Dan Circulo Massage Setelah Latihan Fisik
  2. Traditional Circuit Training Dan Kebugaran Fisik Mahasiswa
  3. Perbandingan Kemampuan Fisik Antara Atlet Pencak Silat Kategori Tanding Dengan Kategori Seni Pada Pelatda Pon Xvii Di Jawa Barat
  4. Kajian Aktivitas Imunostimulan Dari Ekstrak Air Bawang Putih (allium Sativum)
  5. Pemberian Teh Hijau (camellia Sinensis) Terhadap Jumlah Sel Radang Kronis Dan Limfosit T–cd4
  6. Fluktuasi Tekanan Darah, Kadar Endothelin-1 (et-1),dan Nitric Oxide (no) Pada Kehamilan Normal
  7. Profil Serologis Virus Dengue Yang Menginduksi Infeksi Primer Dan Sekunder Dari Beberapa Area Di Jawa Timur
  8. Uji Klinis Transforming Growth Factor 1sebagai Tissue Engineering Padaperawatan Direct Pulp Capping
  9. Peran L-karnitin Dalam Memfasilitasi β-oksidasi Di Mitokondria
  10. Perubahan Gustducin Dan Neutrofil Pada Keadaan Demam
  11. Hipnoterapi Sebagai Analgesik Nyeri Gigi

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